Literature DB >> 2901972

Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors.

P J Birch1, C J Grossman, A G Hayes.   

Abstract

The antagonist profile of kynurenate and FG9041 have been characterised in a modified preparation of the baby rat hemisected spinal cord. Both kynurenate and FG9041 were competitive antagonists of responses to kainate and AMPA, although neither antagonist was selective for kainate versus AMPA. In contrast, both antagonists produced an apparent unsurmountable antagonism of responses to NMDA, indicating a different mode of action at the NMDA receptor.

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Year:  1988        PMID： 2901972     DOI： 10.1016/0014-2999(88)90814-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  34 in total

1.  Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

Authors:  Dénes Zádori; Gábor Nyiri; András Szonyi; István Szatmári; Ferenc Fülöp; József Toldi; Tamás F Freund; László Vécsei; Péter Klivényi
Journal:  J Neural Transm (Vienna)       Date:  2010-12-31       Impact factor: 3.575

2.  Stacking interaction and its role in kynurenic acid binding to glutamate ionotropic receptors.

Authors:  Alexander V Zhuravlev; Gennady A Zakharov; Boris F Shchegolev; Elena V Savvateeva-Popova
Journal:  J Mol Model       Date:  2011-08-12       Impact factor: 1.810

3.  Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice.

Authors:  Andy N Mead; Geraldine Brown; Julie Le Merrer; David N Stephens
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

4.  An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

Authors:  S J Pearson; A Meldrum; G P Reynolds
Journal:  J Neural Transm Gen Sect       Date:  1995

Review 5.  Where does a migraine attack originate? In the brainstem.

Authors:  J Tajti; D Szok; Á Párdutz; B Tuka; A Csáti; A Kuris; J Toldi; L Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2012-03-18       Impact factor: 3.575

6.  Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.

Authors:  M Andreasen; J D Lambert; M S Jensen
Journal:  J Physiol       Date:  1989-07       Impact factor: 5.182

Review 7.  The kynurenine pathway and the brain: Challenges, controversies and promises.

Authors:  Robert Schwarcz; Trevor W Stone
Journal:  Neuropharmacology       Date:  2016-08-07       Impact factor: 5.250

8.  Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat.

Authors:  A J Verberne; P M Beart; W J Louis
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

9.  A novel kynurenic acid analogue: a comparison with kynurenic acid. An in vitro electrophysiological study.

Authors:  Máté Marosi; Dávid Nagy; Tamás Farkas; Zsolt Kis; Eva Rózsa; Hermina Robotka; Ferenc Fülöp; László Vécsei; József Toldi
Journal:  J Neural Transm (Vienna)       Date:  2009-12-02       Impact factor: 3.575

10.  Branched-chain amino acids alter neurobehavioral function in rats.

Authors:  Anna Coppola; Brett R Wenner; Olga Ilkayeva; Robert D Stevens; Mauro Maggioni; Theodore A Slotkin; Edward D Levin; Christopher B Newgard
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-12-18       Impact factor: 4.310
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