Literature DB >> 2901829

Enkephalin is liberated from metorphamide and dynorphin A1-8 by endo-oligopeptidase A, but not by metalloendopeptidase EC 3.4.24.15.

O Toffoletto1, K M Metters, E B Oliveira, A C Camargo, J Rossier.   

Abstract

It has been previously reported that both the cysteinyl-endo-oligopeptidase A and the metalloendopeptidase EC 3.4.24.15 are able to generate enkephalin from a number of enkephalin-containing peptides, including dynorphin A1-8. The present study shows that only endo-oligopeptidase A is able to generate [Leu5]enkephalin and [Met5]enkephalin from dynorphin A1-8 and from metorphamide respectively. It is also shown that endo-oligopeptidase A neither hydrolyses the specific EC 3.4.24.15 substrate alpha-N-benzoyl-Gly-Ala-Ala-Phe p-aminobenzoate, nor is inhibited by the specific EC 3.4.24.15 inhibitor N-[1(RS)-carboxy-2-phenylethyl]-alpha-Ala-Ala-Phe p-aminobenzoate.

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Year:  1988        PMID： 2901829      PMCID： PMC1149103          DOI： 10.1042/bj2520035

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Preparation, assay, and partial characterization of a neutral endopeptidase from rabbit brain.

Authors:  A C Camargo; R Shapanka; L J Greene
Journal:  Biochemistry       Date:  1973-04-24       Impact factor: 3.162

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Soluble metalloendopeptidase from rat brain: action on enkephalin-containing peptides and other bioactive peptides.

Authors:  T G Chu; M Orlowski
Journal:  Endocrinology       Date:  1985-04       Impact factor: 4.736

4.  Active site directed N-carboxymethyl peptide inhibitors of a soluble metalloendopeptidase from rat brain.

Authors:  T G Chu; M Orlowski
Journal:  Biochemistry       Date:  1984-07-31       Impact factor: 3.162

5.  Brain endo-oligopeptidase A, a putative enkephalin converting enzyme.

Authors:  A C Camargo; E B Oliveira; O Toffoletto; K M Metters; J Rossier
Journal:  J Neurochem       Date:  1987-04       Impact factor: 5.372

6.  Purification of rabbit brain endooligopeptidases and preparation of anti-enzyme antibodies.

Authors:  K M Carvalho; A C Camargo
Journal:  Biochemistry       Date:  1981-12-08       Impact factor: 3.162

7.  A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides.

Authors:  M Orlowski; C Michaud; T G Chu
Journal:  Eur J Biochem       Date:  1983-09-01

8.  Conversion and inactivation of opioid peptides by rabbit brain endo-oligopeptidase A.

Authors:  A C Camargo; M J Ribeiro; W N Schwartz
Journal:  Biochem Biophys Res Commun       Date:  1985-07-31       Impact factor: 3.575
  8 in total
  5 in total

1.  Distinction between endo-oligopeptidase A (EC 3.4.22.19) and soluble metalloendopeptidase (EC 3.4.24.15)

Authors:  A C Camargo
Journal:  Biochem J       Date:  1991-07-01       Impact factor: 3.857

2.  Thimet oligopeptidase (EC 3.4.24.15): the same by any name?

Authors:  A J Barrett
Journal:  Biochem J       Date:  1991-07-01       Impact factor: 3.857

3.  Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.

Authors:  M Orlowski; S Reznik; J Ayala; A R Pierotti
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

4.  Enzymatic inactivation of bradykinin by rat brain neuronal perikarya.

Authors:  E A DelBel; A P Padovan; G J Padovan; O Z Sellinger; A R Martins
Journal:  Cell Mol Neurobiol       Date:  1989-09       Impact factor: 5.046

5.  Rat thimet oligopeptidase: large-scale expression in Escherichia coli and characterization of the recombinant enzyme.

Authors:  N McKie; P M Dando; M A Brown; A J Barrett
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857
  5 in total

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