Hong-Ming Chen1, Vincent Chin-Hung Chen1, Tsu-Nai Wang2, Mong-Liang Lu3, Yin-Cheng Huang4, Michael E Dewey5, Johnny Kuang-Wu Lee6, Ching-Piao Tsai7. 1. Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan; School of Medicine, Chang Gung University, Taiwan. 2. Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: wangtn@cc.kmu.edu.tw. 3. Department of Psychiatry, Wan-Fang Hospital & School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 4. School of Medicine, Chang Gung University, Taiwan; Department of Neurosurgery, Chang Gung Memorial Hospital at Chiayi, Taiwan. 5. Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address: michael.dewey@kcl.ac.uk. 6. General Education Center, University of Taipei, Taipei, Taiwan. 7. Department of Neurology, Taipei Veterans General Hospital, Taiwan; Department of Biotechnology, Asia University, Taiwan. Electronic address: cptsai@vghtpe.gov.tw.
Abstract
OBJECTIVE: Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study. METHODS: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010. These cases were compared with 6568 gender-, age-, residence-, and insurance premium-matched controls. Both suicide and non-suicide study patients were drawn from a group with previous psychiatric diagnoses. The risk of suicide among patients with diseases of the pancreas was analyzed using a conditional logistic regression model that controlled for alcohol-related disorder, drug dependence, schizophrenia, depressive disorder, bipolar disorder, anxiety disorder, Charlson comorbidity score, and outpatient visits. RESULTS: Disease of the pancreas was an independent risk factor for psychiatric patients who had completed suicide when adjusted for clinical and other comorbid factors. Among these covariates, alcohol-related disorders partially mediate the suicide risk among patients with disease of the pancreas, and mental disorders may not mediate this suicide risk. CONCLUSIONS: Diseases of the pancreas were associated with increased risk of completed suicide after controlling for potential confounding factors.
OBJECTIVE:Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study. METHODS: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010. These cases were compared with 6568 gender-, age-, residence-, and insurance premium-matched controls. Both suicide and non-suicide study patients were drawn from a group with previous psychiatric diagnoses. The risk of suicide among patients with diseases of the pancreas was analyzed using a conditional logistic regression model that controlled for alcohol-related disorder, drug dependence, schizophrenia, depressive disorder, bipolar disorder, anxiety disorder, Charlson comorbidity score, and outpatient visits. RESULTS: Disease of the pancreas was an independent risk factor for psychiatricpatients who had completed suicide when adjusted for clinical and other comorbid factors. Among these covariates, alcohol-related disorders partially mediate the suicide risk among patients with disease of the pancreas, and mental disorders may not mediate this suicide risk. CONCLUSIONS:Diseases of the pancreas were associated with increased risk of completed suicide after controlling for potential confounding factors.