Literature DB >> 29017052

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy.

W Nathaniel Brennen1, John T Isaacs2.   

Abstract

In this issue of Cancer Cell, Bluemn et al. report that ∼20% of metastatic castration-resistant prostate cancers express neither AR nor neuroendocrine genes and show AR pathway-independent growth, driven instead by a FGFR/MAPK/ID1 signaling cascade. These results provide a strong rationale for co-targeting AR bypass pathways with initial AR antagonism.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 29017052     DOI： 10.1016/j.ccell.2017.09.011

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

Review 1.  Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.

Authors:  Ugo Testa; Germana Castelli; Elvira Pelosi
Journal:  Medicines (Basel)       Date:  2019-07-30

Review 2.  Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain.

Authors:  N G R Dayan Elshan; Matthew B Rettig; Michael E Jung
Journal:  Med Res Rev       Date:  2018-11-22       Impact factor: 12.944

3.  Elevated phospholipase D activity in androgen-insensitive prostate cancer cells promotes both survival and metastatic phenotypes.

Authors:  Matthew Utter; Sohag Chakraborty; Limor Goren; Lucas Feuser; Yuan-Shan Zhu; David A Foster
Journal:  Cancer Lett       Date:  2018-03-08       Impact factor: 8.679

Review 4.  Resolving the Coffey Paradox: what does the androgen receptor do in normal vs. malignant prostate epithelial cells?

Authors:  John T Isaacs
Journal:  Am J Clin Exp Urol       Date:  2018-04-01

5.  Investigation of the effect of meclofenamic acid on the proteome of LNCaP cells reveals changes in alternative polyadenylation and splicing machinery.

Authors:  Busra Sahinoz Saglam; Aylin Kanli; Sevinc Yanar; Murat Kasap; Gurler Akpinar
Journal:  Med Oncol       Date:  2022-09-07       Impact factor: 3.738

6.  Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.

Authors:  Yongjie Ma; Xiaohan Zhang; Omar Awad Alsaidan; Xiangkun Yang; Essilvo Sulejmani; Junyi Zha; Zanna Beharry; Hanwen Huang; Michael Bartlett; Zachary Lewis; Houjian Cai
Journal:  Mol Cancer Res       Date:  2020-10-19       Impact factor: 6.333

Review 7.  Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer.

Authors:  Galina Gritsina; Wei-Qiang Gao; Jindan Yu
Journal:  Asian J Androl       Date:  2019 May-Jun       Impact factor: 3.285
  7 in total

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