Literature DB >> 29017030

Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

Ben Ewen-Campen1, Stephanie E Mohr2, Yanhui Hu2, Norbert Perrimon3.   

Abstract

Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.
Copyright © 2017 Elsevier Inc. All rights reserved.

Mesh：

Year:  2017        PMID： 29017030     DOI： 10.1016/j.devcel.2017.09.020

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  14 in total

1.  Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies.

Authors:  Jonathan Zirin; Yanhui Hu; Luping Liu; Donghui Yang-Zhou; Ryan Colbeth; Dong Yan; Ben Ewen-Campen; Rong Tao; Eric Vogt; Sara VanNest; Cooper Cavers; Christians Villalta; Aram Comjean; Jin Sun; Xia Wang; Yu Jia; Ruibao Zhu; Ping Peng; Jinchao Yu; Da Shen; Yuhao Qiu; Limmond Ayisi; Henna Ragoowansi; Ethan Fenton; Senait Efrem; Annette Parks; Kuniaki Saito; Shu Kondo; Liz Perkins; Stephanie E Mohr; Jianquan Ni; Norbert Perrimon
Journal:  Genetics       Date:  2020-02-18       Impact factor: 4.562

2.  Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.

Authors:  Stéphanie Debrulle; Charlotte Baudouin; Maria Hidalgo-Figueroa; Barbara Pelosi; Cédric Francius; Vincent Rucchin; Kara Ronellenfitch; Robert L Chow; Fadel Tissir; Soo-Kyung Lee; Frédéric Clotman
Journal:  Cell Mol Life Sci       Date:  2019-12-10       Impact factor: 9.261

3.  Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform.

Authors:  Thomas Gonatopoulos-Pournatzis; Michael Aregger; Kevin R Brown; Shaghayegh Farhangmehr; Ulrich Braunschweig; Henry N Ward; Kevin C H Ha; Alexander Weiss; Maximilian Billmann; Tanja Durbic; Chad L Myers; Benjamin J Blencowe; Jason Moffat
Journal:  Nat Biotechnol       Date:  2020-03-16       Impact factor: 54.908

4.  Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes.

Authors:  Akira Terakawa; Yanhui Hu; Toshiya Kokaji; Katsuyuki Yugi; Keigo Morita; Satoshi Ohno; Yifei Pan; Yunfan Bai; Andrey A Parkhitko; Xiaochun Ni; John M Asara; Martha L Bulyk; Norbert Perrimon; Shinya Kuroda
Journal:  iScience       Date:  2022-04-08

5.  Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities.

Authors:  Marcus R Kelly; Kaja Kostyrko; Kyuho Han; Nancie A Mooney; Edwin E Jeng; Kaitlyn Spees; Phuong T Dinh; Keene L Abbott; Dana M Gwinn; E Alejandro Sweet-Cordero; Michael C Bassik; Peter K Jackson
Journal:  Cancer Discov       Date:  2020-07-29       Impact factor: 38.272

Review 6.  IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Authors:  John B Allard; Cunming Duan
Journal:  Front Endocrinol (Lausanne)       Date:  2018-04-09       Impact factor: 5.555

7.  Discovering Health Benefits of Phytochemicals with Integrated Analysis of the Molecular Network, Chemical Properties and Ethnopharmacological Evidence.

Authors:  Sunyong Yoo; Kwansoo Kim; Hojung Nam; Doheon Lee
Journal:  Nutrients       Date:  2018-08-08       Impact factor: 5.717

8.  Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells.

Authors:  Raghuvir Viswanatha; Zhongchi Li; Yanhui Hu; Norbert Perrimon
Journal:  Elife       Date:  2018-07-27       Impact factor: 8.140

9.  Evolutionary history of the medaka long-wavelength sensitive genes and effects of artificial regression by gene loss on behavioural photosensitivity.

Authors:  Yumi Harada; Megumi Matsuo; Yasuhiro Kamei; Mayuko Goto; Shoji Fukamachi
Journal:  Sci Rep       Date:  2019-02-25       Impact factor: 4.379

Review 10.  Engineering the Drosophila Genome for Developmental Biology.

Authors:  Dagmara Korona; Stefan A Koestler; Steven Russell
Journal:  J Dev Biol       Date:  2017-12-11
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