Iannis E Adamopoulos1,2. 1. Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis. 2. Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children-Northern California, Sacramento, California, USA.
Abstract
PURPOSE OF REVIEW: Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors, and the proximity of various cells to bone surfaces influence this process. Inflammatory changes at the bone microenvironment result in alterations leading to both excessive bone loss and bone formation. Detailed understanding of the physiological and pathological mechanisms that dictate these changes will allow us to harness inflammatory signals in bone regeneration. RECENT FINDINGS: Recent reports have suggested that inflammatory signals are able to stimulate transcription factors that regulate osteoblast differentiation from their precursors. SUMMARY: In this review, we summarized current understanding of the roles of inflammation in bone resorption and bone formation, which give rise to different disorders and discuss the huge potential of harnessing these inflammatory signals to achieve bone regeneration.
PURPOSE OF REVIEW: Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors, and the proximity of various cells to bone surfaces influence this process. Inflammatory changes at the bone microenvironment result in alterations leading to both excessive bone loss and bone formation. Detailed understanding of the physiological and pathological mechanisms that dictate these changes will allow us to harness inflammatory signals in bone regeneration. RECENT FINDINGS: Recent reports have suggested that inflammatory signals are able to stimulate transcription factors that regulate osteoblast differentiation from their precursors. SUMMARY: In this review, we summarized current understanding of the roles of inflammation in bone resorption and bone formation, which give rise to different disorders and discuss the huge potential of harnessing these inflammatory signals to achieve bone regeneration.
Authors: Eileen M Shore; Meiqi Xu; George J Feldman; David A Fenstermacher; Tae-Joon Cho; In Ho Choi; J Michael Connor; Patricia Delai; David L Glaser; Martine LeMerrer; Rolf Morhart; John G Rogers; Roger Smith; James T Triffitt; J Andoni Urtizberea; Michael Zasloff; Matthew A Brown; Frederick S Kaplan Journal: Nat Genet Date: 2006-04-23 Impact factor: 38.330
Authors: L C Gerstenfeld; T J Cho; T Kon; T Aizawa; A Tsay; J Fitch; G L Barnes; D T Graves; T A Einhorn Journal: J Bone Miner Res Date: 2003-09 Impact factor: 6.741
Authors: Antonios O Aliprantis; Yasuyoshi Ueki; Rosalyn Sulyanto; Arnold Park; Kirsten S Sigrist; Sudarshana M Sharma; Michael C Ostrowski; Bjorn R Olsen; Laurie H Glimcher Journal: J Clin Invest Date: 2008-10-09 Impact factor: 14.808
Authors: Robin K Suda; Paul C Billings; Kevin P Egan; Jung-Hoon Kim; Ruth McCarrick-Walmsley; David L Glaser; David L Porter; Eileen M Shore; Robert J Pignolo Journal: Stem Cells Date: 2009-09 Impact factor: 6.277
Authors: K Kobayashi; N Takahashi; E Jimi; N Udagawa; M Takami; S Kotake; N Nakagawa; M Kinosaki; K Yamaguchi; N Shima; H Yasuda; T Morinaga; K Higashio; T J Martin; T Suda Journal: J Exp Med Date: 2000-01-17 Impact factor: 14.307
Authors: F Arai; T Miyamoto; O Ohneda; T Inada; T Sudo; K Brasel; T Miyata; D M Anderson; T Suda Journal: J Exp Med Date: 1999-12-20 Impact factor: 14.307
Authors: Omar H Khalaf; Sankar P Chaki; Daniel G Garcia-Gonzalez; Larry J Suva; Dana Gaddy; Angela M Arenas-Gamboa Journal: Infect Immun Date: 2020-03-23 Impact factor: 3.441
Authors: Berenice Rivera-Paredez; Amado D Quezada-Sánchez; Karina Robles-Rivera; Alberto Hidalgo-Bravo; Edgar Denova-Gutiérrez; Guadalupe León-Reyes; Yvonne N Flores; Jorge Salmerón; Rafael Velázquez-Cruz Journal: Osteoporos Int Date: 2022-05-28 Impact factor: 5.071
Authors: Zaida Salmón-González; Javier Anchuelo; Juan C Borregán; Alvaro Del Real; José A Riancho; Carmen Valero Journal: Rep Pract Oncol Radiother Date: 2021-04-14