| Literature DB >> 29016312 |
John Oludele1, Birgitta Lesko2,3, Isabel Mahumane Gundane1, Fernanda de Bruycker-Nogueira4, Argentina Muianga1, Sadia Ali1, Flora Mula1, Imelda Chelene1, Kerstin I Falk5,2, Flávia Barreto Dos Santos4, Eduardo Samo Gudo1.
Abstract
After the report of an outbreak of dengue virus serotype 2 in 2014 in Nampula and Pemba cities, northern Mozambique, a surveillance system was established by the National Institute of Health. A study was performed during 2015-2016 to monitor the trend of the outbreak and confirm the circulating serotype of dengue virus (DENV). After the inclusion of consenting patients who met the case definition, samples from 192 patients were tested for the presence of nonstructural protein 1 antigen, and 60/192 (31%) samples were positive. Further analysis included DENV IgM antibodies, with 39 (20%) IgM positive cases. Reverse transcriptase (RT) PCR was performed for identification of the prevailing DENV serotype; 21/23 tested samples were DENV-2 positive, with DENV-2 present in both affected cities. When sequencing DENV, phenotype Cosmopolitan was identified. The surveillance indicates ongoing spread of DENV-2 in northern Mozambique 2 years after the first report of the outbreak.Entities:
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Year: 2017 PMID： 29016312 PMCID： PMC5817774 DOI： 10.4269/ajtmh.17-0317
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345