Literature DB >> 2900480

Postmortem stability of somatostatin in brain tissue.

P E Cooper1, Q Rahman, T Phillips, J Tu.   

Abstract

The stability of somatostatin (SS) in brain tissue was studied in human material obtained post-mortem and in the rat. In both human and rat brain, loss of SS was found to occur in tissue frozen to -70 degrees C. In the rat, this loss varied from 26 to 70 percent depending on the type of tissue processing used. These data suggest that, for the study of SS in post-mortem brain, use of frozen material should be avoided.

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Year:  1988        PMID： 2900480     DOI： 10.1007/bf00973289

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  4 in total

1.  Postmortem stability of somatostatin-like immunoreactivity in mouse brain under conditions simulating handling of human autopsy material.

Authors:  P Davies; A Thompson
Journal:  Neurochem Res       Date:  1981-07       Impact factor: 3.996

2.  Chromatographic and biological properties of immunoreactive somatostatin in hypothalamic and extrahypothalamic brain regions of the rat.

Authors:  O P Rorstad; J Epelbaum; P Brazeau; J B Martin
Journal:  Endocrinology       Date:  1979-11       Impact factor: 4.736

3.  The regional distribution of somatostatin, substance P and neurotensin in human brain.

Authors:  P E Cooper; M H Fernstrom; O P Rorstad; S E Leeman; J B Martin
Journal:  Brain Res       Date:  1981-08-10       Impact factor: 3.252

4.  Somatostatin is increased in the basal ganglia in Huntington disease.

Authors:  N Aronin; P E Cooper; L J Lorenz; E D Bird; S M Sagar; S E Leeman; J B Martin
Journal:  Ann Neurol       Date:  1983-05       Impact factor: 10.422
  4 in total

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