Literature DB >> 2900319

Zacopride, a potent 5-HT3 antagonist.

W W Smith1, L F Sancilio, J B Owera-Atepo, R J Naylor, L Lambert.   

Abstract

The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205-930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties.

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Year:  1988        PMID： 2900319     DOI： 10.1111/j.2042-7158.1988.tb05253.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  23 in total

1.  Identification and distribution of 5-HT3 recognition sites in the rat gastrointestinal tract.

Authors:  S Champaneria; B Costall; R J Naylor; D W Robertson
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

Review 2.  5-HT3 receptor antagonists and migraine therapy.

Authors:  M D Ferrari
Journal:  J Neurol       Date:  1991       Impact factor: 4.849

3.  Characterization of 5-HT3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro.

Authors:  R M Eglen; S R Swank; L K Walsh; R L Whiting
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

4.  Topographical distribution of 5-HT3 receptor recognition sites in the ferret brain stem.

Authors:  J M Barnes; N M Barnes; B Costall; I L Naylor; R J Naylor; J A Rudd
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-07       Impact factor: 3.000

5.  5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum.

Authors:  B Costall; R J Naylor; B R Tuladhar
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

Review 6.  5-HT3 receptor antagonists. An overview of their present status and future potential in cancer therapy-induced emesis.

Authors:  M S Aapro
Journal:  Drugs       Date:  1991-10       Impact factor: 9.546

7.  The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and involvement of serotonin-3 receptors.

Authors:  Zheng-Ming Ding; Scott M Oster; Sarah R Hall; Eric A Engleman; Sheketha R Hauser; William J McBride; Zachary A Rodd
Journal:  Psychopharmacology (Berl)       Date:  2011-02-23       Impact factor: 4.530

8.  Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat.

Authors:  S E File; A L Johnston
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

9.  Synthesis and evaluation of (S)-[(18)F]fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors.

Authors:  Neema K Pithia; Christopher Liang; Xiang-Zuo Pan; Min-Liang Pan; Jogeshwar Mukherjee
Journal:  Bioorg Med Chem Lett       Date:  2016-03-08       Impact factor: 2.823

10.  5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

Authors:  Amy S Newman; Nikolaos Batis; Gillian Grafton; Francesca Caputo; Catherine A Brady; Jeremy J Lambert; John A Peters; John Gordon; Keith L Brain; Andrew D Powell; Nicholas M Barnes
Journal:  Br J Pharmacol       Date:  2013-07       Impact factor: 8.739
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