Literature DB >> 2900007

Palmitoyl carnitine: an endogenous promotor of calcium efflux from rat heart mitochondria.

A R Baydoun1, A Markham, R M Morgan, A J Sweetman.   

Abstract

The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5-40 microM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P less than 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 +/- 0.11 microM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10-100 microM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+-Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.

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Year:  1988        PMID： 2900007     DOI： 10.1016/0006-2952(88)90307-3

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  10 in total

1.  Calcium- and ADP-magnesium-induced respiratory uncoupling in isolated cardiac mitochondria: influence of cyclosporin A.

Authors:  E Sentex; A Laurent; L Martine; S Gregoire; L Rochette; L Demaison
Journal:  Mol Cell Biochem       Date:  1999-12       Impact factor: 3.396

2.  Dietary oxysterols induce in vivo toxicity of coronary endothelial and smooth muscle cells.

Authors:  Alexandra Meynier; Agnès Andre; Jeanine Lherminier; André Grandgirard; Luc Demaison
Journal:  Eur J Nutr       Date:  2005-01-27       Impact factor: 5.614

3.  The effects of novel vasodilator long chain acyl carnitine esters in the isolated perfused heart of the rat.

Authors:  D N Criddle; G H Dewar; W B Wathey; B Woodward
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

4.  L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos.

Authors:  Jyotshnabala Kanungo; Elvis Cuevas; Syed F Ali; Merle G Paule
Journal:  Reprod Toxicol       Date:  2011-10-20       Impact factor: 3.143

5.  Bay K 8644, modifier of calcium transport and energy metabolism in rat heart mitochondria: a new intracellular site of action.

Authors:  A R Baydoun; A Markham; R M Morgan; A J Sweetman
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

6.  Acetyl L-carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment.

Authors:  Xiaoqing Guo; Melanie Dumas; Bonnie L Robinson; Syed F Ali; Merle G Paule; Qiang Gu; Jyotshna Kanungo
Journal:  J Appl Toxicol       Date:  2016-05-18       Impact factor: 3.446

Review 7.  Acylcarnitines--old actors auditioning for new roles in metabolic physiology.

Authors:  Colin S McCoin; Trina A Knotts; Sean H Adams
Journal:  Nat Rev Endocrinol       Date:  2015-08-25       Impact factor: 43.330

Review 8.  Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?

Authors:  A Markham; R Bains; P Franklin; M Spedding
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

Review 9.  Recent Advances in the Pathophysiology of Fatty Acid Oxidation Defects: Secondary Alterations of Bioenergetics and Mitochondrial Calcium Homeostasis Caused by the Accumulating Fatty Acids.

Authors:  Alexandre Umpierrez Amaral; Moacir Wajner
Journal:  Front Genet       Date:  2020-11-27       Impact factor: 4.599

10.  Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.

Authors:  M Kerr; K M J H Dennis; C A Carr; W Fuller; G Berridge; S Rohling; C L Aitken; C Lopez; R Fischer; J J Miller; K Clarke; D J Tyler; L C Heather
Journal:  FASEB J       Date:  2021-08       Impact factor: 5.191
  10 in total

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