Literature DB >> 2899909

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

T Honoré1, S N Davies, J Drejer, E J Fletcher, P Jacobsen, D Lodge, F E Nielsen.   

Abstract

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.

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Year:  1988        PMID： 2899909     DOI： 10.1126/science.2899909

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  196 in total

1.  Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate.

Authors:  S S Wang; L Khiroug; G J Augustine
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

2.  Glutamate receptor agonists evoked Ca(2+)-dependent and Ca(2+)-independent release of [3H]D-aspartate from cultured chick retina cells.

Authors:  P F Santos; C B Duarte; A P Carvalho
Journal:  Neurochem Res       Date:  1996-03       Impact factor: 3.996

3.  Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.

Authors:  P Stern; F A Edwards; B Sakmann
Journal:  J Physiol       Date:  1992-04       Impact factor: 5.182

4.  Cochlear kainate receptors.

Authors:  Marcello Peppi; Melissa Landa; William F Sewell
Journal:  J Assoc Res Otolaryngol       Date:  2012-01-10

5.  Stargazing from a new vantage--TARP modulation of AMPA receptor pharmacology.

Authors:  Alexander C Jackson; Roger A Nicoll
Journal:  J Physiol       Date:  2011-12-15       Impact factor: 5.182

6.  Glutamate-dopamine interactions in the ventral striatum: role in locomotor activity and responding with conditioned reinforcement.

Authors:  L H Burns; B J Everitt; A E Kelley; T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  1994-08       Impact factor: 4.530

7.  Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.

Authors:  Einar Ö Einarsson; Jennifer Pors; Karim Nader
Journal:  Neuropsychopharmacology       Date:  2014-08-05       Impact factor: 7.853

8.  Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors.

Authors:  Silke Kayser; Jacob C Hansen; Markus Staudt; Aleksandra Moroz; Younes Larsen; Piero Temperini; Feng Yi; Jed T Syrenne; Niels Krogsgaard-Larsen; Stylianos Iliadis; Birgitte Nielsen; Kasper B Hansen; Darryl S Pickering; Lennart Bunch
Journal:  ACS Chem Neurosci       Date:  2020-02-17       Impact factor: 4.418

9.  Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.

Authors:  J L Yakel; P Vissavajjhala; V A Derkach; D A Brickey; T R Soderling
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

10.  Ionotropic non-N-methyl-D-aspartate agonists induce retraction of dendritic spinules from retinal horizontal cells.

Authors:  R Weiler; K Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205
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