Literature DB >> 2899427

Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats.

M S Alam1, R Husain, S P Srivastava, P K Seth.   

Abstract

Exposure to DBTL (20, 40 or 80 mg/kg body weight) caused a decrease in levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) at all treatment levels. Hypothalamus and frontal cortex appeared to be most affected, since levels of all the three amines examined showed changes in these areas. Maximum decrease of DA was found in corpus striatum, NA in pons medulla and of 5-HT in frontal cortex. These animals also showed a decrease in spontaneous locomotor activity and learning at all the doses. The data indicates involvement of hypothalamus and frontal cortical regions of the brain in the neurotoxicity of DBTL.

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Year:  1988        PMID： 2899427     DOI： 10.1007/bf00334618

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  19 in total

1.  Growth, behavior, and brain catecholamines in lead-exposed neonatal rats: a reappraisal.

Authors:  M Golter; I A Michaelson
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2.  The toxicology of tin compounds.

Authors:  J M BARNES; H B STONER
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3.  Behavioral effects of some psychopharmacological agents.

Authors:  L COOK; E WEIDLEY
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4.  Acute effects of organotins on brain, liver and kidney in rats.

Authors:  R S Dwivedi; G Kaur; R C Srivastava; T N Srivastava
Journal:  Ind Health       Date:  1985       Impact factor: 2.179

5.  Method for the rapid determination of norepinephrine, dopamine, and serotonin in the same brain region.

Authors:  D M Jacobowitz; J S Richardson
Journal:  Pharmacol Biochem Behav       Date:  1978-05       Impact factor: 3.533

6.  Effect of acrylamide on biogenic amine levels, monoamine oxidase, and cathepsin D activity of rat brain.

Authors:  R Dixit; R Husain; H Mukhtar; P K Seth
Journal:  Environ Res       Date:  1981-10       Impact factor: 6.498

7.  Behavioral toxicity of acute and subacute exposure to triethyltin in the rat.

Authors:  L Reiter; K Kidd; G Heavner; P Ruppert
Journal:  Neurotoxicology       Date:  1981-01       Impact factor: 4.294

8.  Some behavioral effects of early styrene intoxication in experimental animals.

Authors:  R Husain; S P Srivastava; P K Seth
Journal:  Arch Toxicol       Date:  1985-04       Impact factor: 5.153

9.  Methyl methacrylate induced behavioural and neurochemical changes in rats.

Authors:  R Husain; S P Srivastava; P K Seth
Journal:  Arch Toxicol       Date:  1985-10       Impact factor: 5.153

Review 10.  Toxicity and health effects of selected organotin compounds: a review.

Authors:  R D Kimbrough
Journal:  Environ Health Perspect       Date:  1976-04       Impact factor: 9.031
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  3 in total

1.  Age and sex related behavioral changes induced by dibutyltin-dilaurate in rats.

Authors:  M S Alam; R Husain; P K Seth; S P Srivastava
Journal:  Bull Environ Contam Toxicol       Date:  1993-02       Impact factor: 2.151

2.  6-Hydroxydopamine induced impairment of Pavlovian conditioning in the rabbit.

Authors:  L Winsky; J A Harvey
Journal:  Neurochem Res       Date:  1992-05       Impact factor: 3.996

Review 3.  Organotins in Neuronal Damage, Brain Function, and Behavior: A Short Review.

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Journal:  Front Endocrinol (Lausanne)       Date:  2018-01-08       Impact factor: 5.555
  3 in total

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