Naohiro Fujimoto1, Tatsuhiko Kubo2, Masanori Hisaoka3, Kazuma Udo4, Akira Yokomizo5, Tadamasa Shibuya6, Hironobu Wakeda7, Kiyoaki Nishihara8, Ryosuke Moriya1, Keiko Iwakuma1. 1. Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan. 2. Department of Public Health, University of Occupational and Environmental Health, Kitakyushu, Japan. 3. Department of Pathology and Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan. 4. Department of Urology, Saga University, Saga, Japan. 5. Department of Urology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan. 6. Department of Urology, Oita University, Oita, Japan. 7. Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. 8. Department of Urology, Kurume University, Kurume, Japan.
Abstract
OBJECTIVES: To show the demographics, type of treatment and clinical outcomes of patients with retroperitoneal tumors in Japan. METHODS: We carried out a retrospective analysis of patients with retroperitoneal tumors treated between 2000 and 2012 at 12 university hospitals in Japan. Histology was re-evaluated using the 2013 World Health Organization classification. RESULTS: A total of 167 patients were included in the analysis. The number of diagnosed patients increased over the 12-year study period. Liposarcoma and schwannoma were the most common histological types among intermediate/malignant and benign tumors, respectively. The intermediate/malignant tumors were larger and were more frequently found in older people. Surgical resection was the primary treatment for 151 patients. The median survival duration for patients with malignant tumors was 91 months, and was significantly shorter than that for patients with benign and intermediate tumors (P < 0.01). R2 resection was associated with significantly shorter survival than R0/R1 resection for malignant tumors (P < 0.01), but not for intermediate. Grossly complete resection of the recurrent tumors improved survival. CONCLUSION: The number of patients diagnosed with retroperitoneal tumors increased over time. R2 resection of primary tumors was found to be associated with poor prognosis in malignant tumors, but not in intermediate tumors. Complete surgical resection of recurrent tumors was associated with a better oncological outcome.
OBJECTIVES: To show the demographics, type of treatment and clinical outcomes of patients with retroperitoneal tumors in Japan. METHODS: We carried out a retrospective analysis of patients with retroperitoneal tumors treated between 2000 and 2012 at 12 university hospitals in Japan. Histology was re-evaluated using the 2013 World Health Organization classification. RESULTS: A total of 167 patients were included in the analysis. The number of diagnosed patients increased over the 12-year study period. Liposarcoma and schwannoma were the most common histological types among intermediate/malignant and benign tumors, respectively. The intermediate/malignant tumors were larger and were more frequently found in older people. Surgical resection was the primary treatment for 151 patients. The median survival duration for patients with malignant tumors was 91 months, and was significantly shorter than that for patients with benign and intermediate tumors (P < 0.01). R2 resection was associated with significantly shorter survival than R0/R1 resection for malignant tumors (P < 0.01), but not for intermediate. Grossly complete resection of the recurrent tumors improved survival. CONCLUSION: The number of patients diagnosed with retroperitoneal tumors increased over time. R2 resection of primary tumors was found to be associated with poor prognosis in malignant tumors, but not in intermediate tumors. Complete surgical resection of recurrent tumors was associated with a better oncological outcome.
Authors: Stefan Niebisch; Holger Staab; Sebastian Ullrich; Karl-Titus Hoffmann; Osama Sabri; René Thieme; Katrin Schierle; Christian Wittekind; Ines Gockel Journal: Int J Surg Case Rep Date: 2019-03-30