Seong-Jang Kim1,2, Sang-Woo Lee3. 1. Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea. 2. Biomedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea. 3. Department of Nuclear Medicine, Kyungpook National University Medical Center and School of Medicine, Daegu, Korea.
Abstract
BACKGROUND AND AIM: We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for prediction of malignant potential of gastrointestinal stromal tumor (GIST) through a systematic review and meta-analysis. METHODS: The MEDLINE, Embase, and Cochrane Library database, from the earliest available date of indexing through May 31, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for prediction of malignant potential of GIST. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. RESULTS: Across seven studies (188 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.88 (95% confidence interval [CI]: 0.80-0.94) without heterogeneity (χ2 = 6.15, P = 0.72) and a pooled specificity of 0.88 (95% CI: 0.75-0.94) with heterogeneity (χ2 = 23.2, P = 0.01). LR syntheses gave an overall LR+ of 7.2 (95% CI: 3.3-15.3) and LR- of 0.13 (95% CI: 0.07-0.24). The pooled diagnostic odds ratio was 54 (95% CI: 16-181). CONCLUSION: F-18 FDG PET or PET/CT demonstrated good sensitivity and specificity for the prediction of malignant potential of GIST. At present, the literature regarding the use of F-18 FDG PET or PET/CT for the prediction of malignant potential of GIST remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET or PET/CT prediction of malignant potential of GIST.
BACKGROUND AND AIM: We aimed to explore the role of the diagnostic accuracy of F-18fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for prediction of malignant potential of gastrointestinal stromal tumor (GIST) through a systematic review and meta-analysis. METHODS: The MEDLINE, Embase, and Cochrane Library database, from the earliest available date of indexing through May 31, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for prediction of malignant potential of GIST. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. RESULTS: Across seven studies (188 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.88 (95% confidence interval [CI]: 0.80-0.94) without heterogeneity (χ2 = 6.15, P = 0.72) and a pooled specificity of 0.88 (95% CI: 0.75-0.94) with heterogeneity (χ2 = 23.2, P = 0.01). LR syntheses gave an overall LR+ of 7.2 (95% CI: 3.3-15.3) and LR- of 0.13 (95% CI: 0.07-0.24). The pooled diagnostic odds ratio was 54 (95% CI: 16-181). CONCLUSION:F-18 FDG PET or PET/CT demonstrated good sensitivity and specificity for the prediction of malignant potential of GIST. At present, the literature regarding the use of F-18 FDG PET or PET/CT for the prediction of malignant potential of GIST remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET or PET/CT prediction of malignant potential of GIST.