Literature DB >> 2899397

Effect of PGE2 and alpha-adrenergic agonists on AVP-dependent cAMP levels in rabbit and rat CCT.

D Chabardès1, C Brick-Ghannam, M Montégut, S Siaume-Perez.   

Abstract

The effect of prostaglandins and alpha-adrenergic agonists on arginine vasopressin-induced adenosine 3',5'-cyclic monophosphate (cAMP) production was investigated in microdissected rat and rabbit cortical collecting tubules (CCT) incubated in vitro. In rabbit CCT, addition to all media of a prostaglandin synthesis inhibitor increased this production; exogenous prostaglandin E2 (PGE2) induced a reproducible dose-dependent inhibition of cAMP accumulation. Maximal inhibition (mean: 57.5%) was observed with 0.3 microM PGE2, and threshold inhibition was observed with concentrations ranging from 3 to 10 nM PGE2. Inhibition of cAMP levels in rabbit CCT was also obtained with 0.3 microM PGF2 alpha (mean inhibition: 44.3%) but not with alpha-adrenergic agonists studied under the same conditions. The opposite was observed in rat CCT studied in parallel: the alpha-agonists inhibited cAMP production by up to 80%, but PGE2 had no effect.

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Year:  1988        PMID： 2899397     DOI： 10.1152/ajprenal.1988.255.1.F43

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  12 in total

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5.  Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat.

Authors:  K Tomita; H Nonoguchi; F Marumo
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6.  Activation of the simian virus 40 (SV40) genome abrogates sensitivity to AVP in a rabbit collecting tubule cell line by repressing membrane expression of AVP receptors.

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7.  Effect of prostaglandin E2 on agonist-stimulated cAMP accumulation in the distal convoluted tubule isolated from the rabbit kidney.

Authors:  N M Griffiths; C Brick-Ghannam; S Siaume-Perez; D Chabardès
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8.  H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.

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9.  Chloride secretion stimulated by prostaglandin E1 and by forskolin in a canine renal epithelial cell line.

Authors:  N L Simmons
Journal:  J Physiol       Date:  1991-01       Impact factor: 5.182

10.  Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin.

Authors:  D Firsov; L Aarab; B Mandon; S Siaume-Perez; C de Rouffignac; D Chabardès
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