Literature DB >> 28993327

In Vitro Activities of Pexiganan and 10 Comparator Antimicrobials against 502 Anaerobic Isolates Recovered from Skin and Skin Structure Infections.

Ellie J C Goldstein1,2, Diane M Citron3, Kerin L Tyrrell3, Eliza S Leoncio3.   

Abstract

Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. The MIC90s of studied isolates were as follows: Bacteroides fragilis, 16 μg/ml; other B. fragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; Porphyromonas spp., 64 μg/ml; Propionibacterium acnes, 4 μg/ml; Eggerthella lenta and Peptostreptococcus anaerobius, 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for skin and skin structure infections (SSSIs) involving anaerobes.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Bacteroides fragilis; Finegoldia magna; Propionibacterium acnes; anaerobes; clostridia; pexiganan; topical antimicrobials; wound infections

Mesh：

Substances：

Year:  2017        PMID： 28993327      PMCID： PMC5700356          DOI： 10.1128/AAC.01401-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

Review 1.  Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.

Authors:  Deborah A Williamson; Glen P Carter; Benjamin P Howden
Journal:  Clin Microbiol Rev       Date:  2017-07       Impact factor: 26.132

2.  Microbiology of facial cellulitis related to dental infection.

Authors:  Y M Kouassi; B Janvier; X Dufour; G Bouche; J-M Klossek
Journal:  Med Mal Infect       Date:  2011-09-09       Impact factor: 2.152

3.  In Vitro Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.

Authors:  Ellie J C Goldstein; Diane M Citron; Kerin L Tyrrell; Eliza S Leoncio
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

4.  Re-assessment of phenotypic identifications of Bacteroides putredinis to Alistipes species using molecular methods.

Authors:  Kerin L Tyrrell; Yumi A Warren; Diane M Citron; Ellie J C Goldstein
Journal:  Anaerobe       Date:  2011-04-20       Impact factor: 3.331

5.  Bacteriology of human and animal bite wounds.

Authors:  E J Goldstein; D M Citron; B Wield; U Blachman; V L Sutter; T A Miller; S M Finegold
Journal:  J Clin Microbiol       Date:  1978-12       Impact factor: 5.948

6.  Differences in distribution and antimicrobial susceptibility of anaerobes isolated from complicated intra-abdominal infections versus diabetic foot infections.

Authors:  Marina Claros; Diane M Citron; Ellie J C Goldstein; C Vreni Merriam; Kerin L Tyrrell
Journal:  Diagn Microbiol Infect Dis       Date:  2013-05-30       Impact factor: 2.803

7.  Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America.

Authors:  Joseph S Solomkin; John E Mazuski; John S Bradley; Keith A Rodvold; Ellie J C Goldstein; Ellen J Baron; Patrick J O'Neill; Anthony W Chow; E Patchen Dellinger; Soumitra R Eachempati; Sherwood Gorbach; Mary Hilfiker; Addison K May; Avery B Nathens; Robert G Sawyer; John G Bartlett
Journal:  Clin Infect Dis       Date:  2010-01-15       Impact factor: 9.079

8.  Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents.

Authors:  Diane M Citron; Ellie J C Goldstein; C Vreni Merriam; Benjamin A Lipsky; Murray A Abramson
Journal:  J Clin Microbiol       Date:  2007-07-03       Impact factor: 5.948

9.  Beyond the Intensive Care Unit (ICU): Countywide Impact of Universal ICU Staphylococcus aureus Decolonization.

Authors:  Bruce Y Lee; Sarah M Bartsch; Kim F Wong; James A McKinnell; Eric Cui; Chenghua Cao; Diane S Kim; Loren G Miller; Susan S Huang
Journal:  Am J Epidemiol       Date:  2016-02-11       Impact factor: 4.897
  9 in total
  1 in total

Review 1.  Antibiotic Resistance and Mechanisms of Pathogenic Bacteria in Tubo-Ovarian Abscess.

Authors:  Huanna Tang; Hui Zhou; Runju Zhang
Journal:  Front Cell Infect Microbiol       Date:  2022-07-27       Impact factor: 6.073
  1 in total

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