Literature DB >> 2899307

The mode of action of guanidine on mouse motor nerve terminals.

J Molgó1, A Mallart.   

Abstract

The action of guanidine on presynaptic membrane currents has been investigated to elucidate its facilitatory effect on phasic transmitter release at the mouse neuromuscular junction. Guanidine (2-10 mM) produced a near complete inhibition of the fast voltage-dependent K current. This effect is expected to allow an increase in Ca2+ influx and, thereby, in transmitter release upon nerve stimulation. Guanidine failed to block the Ca-dependent K current of the nerve terminals.

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Year:  1988        PMID： 2899307     DOI： 10.1016/0304-3940(88)90374-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  3 in total

1.  Three potassium currents in mouse motor nerve terminals.

Authors:  N Tabti; C Bourret; A Mallart
Journal:  Pflugers Arch       Date:  1989-02       Impact factor: 3.657

Review 2.  3,4-Diaminopyridine, an orphan drug, in the symptomatic treatment of Lambert-Eaton myasthenic syndrome.

Authors:  J Molgó; J M Guglielmi
Journal:  Pflugers Arch       Date:  1996       Impact factor: 3.657

3.  Guanidine affects differentially the twitch response of diaphragm, extensor digitorum longus and soleus nerve-muscle preparations of mice.

Authors:  Rosana Ferrari; Léa Rodrigues-Simioni; Maria Alice da Cruz Höfling
Journal:  Molecules       Date:  2012-06-15       Impact factor: 4.411
  3 in total

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