Jason M Woodbury1, Katarina Bojanić2, Ruža Grizelj3, Alexandre N Cavalcante1, Vinay K Donempudi1, Toby N Weingarten1, Darrell R Schroeder4, Juraj Sprung1. 1. a Department of Anesthesiology and Perioperative Medicine , Mayo Clinic , Rochester , MN , USA. 2. b Division of Neonatology, Department of Obstetrics and Gynecology , University Hospital Merkur , Zagreb , Croatia. 3. c Department of Pediatrics , University of Zagreb, School of Medicine, University Hospital Centre Zagreb , Zagreb , Croatia. 4. d Division of Biomedical Statistics and Informatics , Mayo Clinic , Rochester , MN , USA.
Abstract
OBJECTIVE: The rate of congenital diaphragmatic hernia (CDH) varies, but most reports estimate the incidence to be less than three per 10,000 births. Our objective was to document the incidence of CDH in a geographically well-defined population using available resources for highly accurate incident case ascertainment. METHODS: We ascertained CDH cases in Olmsted County, Minnesota, United States of America, from 1981 through 2014 using resources of the Rochester Epidemiology Project. Overall and sex-specific incidence rates were calculated, and hospital survival was assessed. RESULTS: A total of 26 incident CDH cases were identified; the overall incidence of 3.6 (95% CI, 2.2-5.0) per 10,000 did not differ significantly over the 34-year study period (p = .28). The estimated incidence was 4.3 (95% CI, 2.2-6.5) for male infants and 2.9 (95% CI, 1.1-4.6) for female infants. The percentage of cases diagnosed prenatally was 33% from 1981 through 2000 and 50% from 2001 through 2014. The rate of survival to discharge in the two periods was 50% and 88%. CONCLUSION: The incidence of CDH in Olmsted County exceeds the majority of published rates, which most likely can be attributed to our comprehensive case ascertainment.
OBJECTIVE: The rate of congenital diaphragmatic hernia (CDH) varies, but most reports estimate the incidence to be less than three per 10,000 births. Our objective was to document the incidence of CDH in a geographically well-defined population using available resources for highly accurate incident case ascertainment. METHODS: We ascertained CDH cases in Olmsted County, Minnesota, United States of America, from 1981 through 2014 using resources of the Rochester Epidemiology Project. Overall and sex-specific incidence rates were calculated, and hospital survival was assessed. RESULTS: A total of 26 incident CDH cases were identified; the overall incidence of 3.6 (95% CI, 2.2-5.0) per 10,000 did not differ significantly over the 34-year study period (p = .28). The estimated incidence was 4.3 (95% CI, 2.2-6.5) for male infants and 2.9 (95% CI, 1.1-4.6) for female infants. The percentage of cases diagnosed prenatally was 33% from 1981 through 2000 and 50% from 2001 through 2014. The rate of survival to discharge in the two periods was 50% and 88%. CONCLUSION: The incidence of CDH in Olmsted County exceeds the majority of published rates, which most likely can be attributed to our comprehensive case ascertainment.
Authors: Alessandra Lisi; Lorenzo D Botto; Monica Rittler; Eduardo Castilla; Sebastiano Bianca; Fabrizio Bianchi; Beverley Botting; Hermien De Walle; J David Erickson; Miriam Gatt; Catherine De Vigan; Lorentz Irgens; William Johnson; Paul Lancaster; Paul Merlob; Osvaldo M Mutchinick; Annukka Ritvanen; Elisabeth Robert; Gioacchino Scarano; Claude Stoll; Pierpaolo Mastroiacovo Journal: Am J Med Genet A Date: 2005-04-01 Impact factor: 2.802
Authors: A Tonks; M Wyldes; D A Somerset; K Dent; A Abhyankar; I Bagchi; A Lander; E Roberts; M D Kilby Journal: Prenat Diagn Date: 2004-08 Impact factor: 3.050
Authors: Hans Skari; Kristin Bjornland; Bjorn Frenckner; Lars Goran Friberg; Marja Heikkinen; Timo Hurme; Borger Loe; Gunnhild Mollerlokken; Ole Henrik Nielsen; Niels Qvist; Risto Rintala; Katarina Sandgren; Tomas Wester; Ragnhild Emblem Journal: J Pediatr Surg Date: 2002-09 Impact factor: 2.545