| Literature DB >> 2899237 |
W M Watkins1, J A Oloo, J D Lury, M Mosoba, D Kariuki, M Mjomba, D K Koech, H M Gilles.
Abstract
Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45.4 h and 54.8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.Entities:
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Year: 1988 PMID： 2899237 DOI： 10.1016/s0140-6736(88)92538-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321