Literature DB >> 2899152

Gastric emptying of large single unit dosage forms.

S S Davis1, F Norring-Christensen, R Khosla, L C Feely.   

Abstract

The gastrointestinal transit of two single unit dosage forms has been followed in healthy subjects under different feeding conditions. Transit was affected by the size of the meal administered. When two tablets were given concurrently they often emptied from the stomach at or about the same time, but in a number of cases the two units were seen to empty at widely different times.

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Year:  1988        PMID： 2899152     DOI： 10.1111/j.2042-7158.1988.tb05220.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  10 in total

Review 1.  Gamma scintigraphy in the evaluation of pharmaceutical dosage forms.

Authors:  S S Davis; J G Hardy; S P Newman; I R Wilding
Journal:  Eur J Nucl Med       Date:  1992

2.  Biochemical and mechanical characterization of enzyme-digestible hydrogels.

Authors:  W S Shalaby; K Park
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

3.  Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.

Authors:  A J Coupe; S S Davis; I R Wilding
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

4.  Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation.

Authors:  M Brunner; S Ziegler; A F D Di Stefano; P Dehghanyar; K Kletter; M Tschurlovits; R Villa; R Bozzella; G Celasco; L Moro; A Rusca; R Dudczak; M Müller
Journal:  Br J Clin Pharmacol       Date:  2006-01       Impact factor: 4.335

5.  Correlation of the gastric emptying of nondisintegrating tablets with gastrointestinal motility.

Authors:  A J Coupe; S S Davis; D F Evans; I R Wilding
Journal:  Pharm Res       Date:  1991-10       Impact factor: 4.200

6.  Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.

Authors:  S S Davis; N Washington; G D Parr; A H Short; V A John; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

Review 7.  A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

Authors:  Ahmad Y Abuhelwa; David J R Foster; Richard N Upton
Journal:  AAPS J       Date:  2016-07-20       Impact factor: 4.009

8.  Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers.

Authors:  I R Wilding; S S Davis; J G Hardy; C S Robertson; V A John; M L Powell; M Leal; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1991-11       Impact factor: 4.335

9.  Erythromycin accelerates solid emptying at the expense of gastric sieving.

Authors:  H C Lin; S L Sanders; Y G Gu; J E Doty
Journal:  Dig Dis Sci       Date:  1994-01       Impact factor: 3.199

10.  Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product.

Authors:  Beth R Cameron; Ludvina Ferreira; I David MacDonald
Journal:  BMC Pharmacol Toxicol       Date:  2020-12-14       Impact factor: 2.483
  10 in total

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