Árpád Kormányos1, Péter Domsik1, Anita Kalapos1, Andrea Orosz2, Csaba Lengyel3, Zsuzsanna Valkusz3, Attila Trencsányi3, Tamás Forster1, Attila Nemes1. 1. 2nd Department of Medicine and Cardiology Centre, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. 2. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. 3. 1st Department of Medicine, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Abstract
INTRODUCTION: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone-secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. METHODS: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age- and gender-matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). RESULTS: In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so-called LV "rigid body rotation" (RBR). Between all acromegalic patients without LV-RBR and controls, both LV basal (-3.76 ± 1.73 vs. -6.17 ± 2.66°, P = .004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P = .001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P < .001) differed significantly. Between active and nonactive acromegaly subgroups, only the time-to-peak LV twist (377 ± 78 vs. 229 ± 97 ms, P = .005) showed significant difference. CONCLUSIONS: Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.
INTRODUCTION:Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone-secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalicpatients and to compare their results to age- and gender-matched healthy controls. METHODS: The present study comprised 24 acromegalicpatients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age- and gender-matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). RESULTS: In 4 out of 20 acromegalicpatients, LV showed near absence of twist, as the so-called LV "rigid body rotation" (RBR). Between all acromegalicpatients without LV-RBR and controls, both LV basal (-3.76 ± 1.73 vs. -6.17 ± 2.66°, P = .004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P = .001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P < .001) differed significantly. Between active and nonactive acromegaly subgroups, only the time-to-peak LV twist (377 ± 78 vs. 229 ± 97 ms, P = .005) showed significant difference. CONCLUSIONS:Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.
Authors: Attila Nemes; Gergely Rácz; Árpád Kormányos; Péter Domsik; Anita Kalapos; Nándor Gyenes; Nóra Ambrus; István Hartyánszky; Gábor Bogáts; Kálmán Havasi Journal: Cardiovasc Diagn Ther Date: 2021-04
Authors: Bernadett Borda; Árpád Kormányos; Péter Domsik; Anita Kalapos; Csaba Lengyel; Nóra Ambrus; György Lázár; Tamás Forster; Attila Nemes Journal: Quant Imaging Med Surg Date: 2018-12
Authors: Árpád Kormányos; Anita Kalapos; Péter Domsik; Nándor Gyenes; Nóra Ambrus; Zsuzsanna Valkusz; Csaba Lengyel; Attila Nemes Journal: Quant Imaging Med Surg Date: 2020-03