Nonika Rajkumari1, Purva Mathur2, Amit K Gupta3, Kumkum Sharma3, Mahesh C Misra4. 1. Department of Laboratory Medicine (Microbiology Division), Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India. 2. Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, India. 3. Hospital Infection Control Unit, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India. 4. Department of Surgery, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Abstract
BACKGROUND: Infections by uncommon non-fermenting Gram negative bacteria are on the rise, but little is known about the risk factors and drug resistance in trauma patients in India. This study explored the infections caused by Stenotrophomonas maltophilia and/or Burkholderia cepacia in trauma patients over a period of 5 years. MATERIAL AND METHODS: Patients admitted for trauma care with S. maltophilia and/or B. cepacia isolated from clinical specimens were enrolled. Characteristics regarding the strain isolation, drug sensitivity pattern, multidrug resistance (MDR), patient, outcomes, and differentiation of true infection from colonisation were observed. RESULTS: Of the total 233 isolates, 102 were S. maltophilia and 131 were B. cepacia; 4.3% were responsible for polymicrobial infections with other bacteria. There were more B. cepacia MDR isolates than S. maltophilia. Maximum resistance was found to tetracycline (86.7%) and tobramycin (86.7%) in B. cepacia and to co-trimoxazole (68.7%) in S. maltophilia. Of these, 21 (16.03%) had a fatal outcome and the remaining 111 (84.7%) were discharged healthy. The in-hospital mortality rate associated with B. cepacia was much (16%) higher than S. maltophilia (13%) at this centre. CONCLUSION: The analysis of epidemiology and outcome of these infections will help to inform their management and treatment.
BACKGROUND:Infections by uncommon non-fermenting Gram negative bacteria are on the rise, but little is known about the risk factors and drug resistance in traumapatients in India. This study explored the infections caused by Stenotrophomonas maltophilia and/or Burkholderia cepacia in traumapatients over a period of 5 years. MATERIAL AND METHODS:Patients admitted for trauma care with S. maltophilia and/or B. cepacia isolated from clinical specimens were enrolled. Characteristics regarding the strain isolation, drug sensitivity pattern, multidrug resistance (MDR), patient, outcomes, and differentiation of true infection from colonisation were observed. RESULTS: Of the total 233 isolates, 102 were S. maltophilia and 131 were B. cepacia; 4.3% were responsible for polymicrobial infections with other bacteria. There were more B. cepacia MDR isolates than S. maltophilia. Maximum resistance was found to tetracycline (86.7%) and tobramycin (86.7%) in B. cepacia and to co-trimoxazole (68.7%) in S. maltophilia. Of these, 21 (16.03%) had a fatal outcome and the remaining 111 (84.7%) were discharged healthy. The in-hospital mortality rate associated with B. cepacia was much (16%) higher than S. maltophilia (13%) at this centre. CONCLUSION: The analysis of epidemiology and outcome of these infections will help to inform their management and treatment.
Entities:
Keywords:
Bacteria; epidemology; infection; infection prevention and control; surveillance
Authors: Louis J Magnotti; Martin A Croce; Ben L Zarzaur; Joseph M Swanson; G Christopher Wood; Jordan A Weinberg; Timothy C Fabian Journal: J Am Coll Surg Date: 2011-04 Impact factor: 6.113
Authors: G Christopher Wood; Eric W Mueller; Martin A Croce; Bradley A Boucher; Scott D Hanes; Timothy C Fabian Journal: Surg Infect (Larchmt) Date: 2005 Impact factor: 2.150
Authors: F Vidal; J Mensa; M Almela; M Olona; J A Martínez; F Marco; M J López; A Soriano; J P Horcajada; J M Gatell; C Richart Journal: QJM Date: 2003-03
Authors: K Takigawa; J Fujita; K Negayama; Y Yamagishi; Y Yamaji; K Ouchi; K Yamada; M Abe; T Nakazawa; K Kawanishi Journal: Kansenshogaku Zasshi Date: 1993-11
Authors: Yu Lin Wang; Marco R Scipione; Yanina Dubrovskaya; John Papadopoulos Journal: Antimicrob Agents Chemother Date: 2013-10-21 Impact factor: 5.191