Aurélie Velay1, Morgane Solis2, Wallys Kack-Kack2, Pierre Gantner2, Marianne Maquart3, Martin Martinot4, Olivier Augereau5, Dominique De Briel5, Pierre Kieffer6, Caroline Lohmann7, Jean Dominique Poveda8, Emmanuelle Cart-Tanneur9, Xavier Argemi10, Isabelle Leparc-Goffart3, Sylvie de Martino11, Benoit Jaulhac11, Sophie Raguet12, Marie-Josée Wendling13, Yves Hansmann10, Samira Fafi-Kremer2. 1. Virology Laboratory, University Hospital of Strasbourg, F-67000 Strasbourg, France; INSERM, IRM UMR_S 1109, F-67000 Strasbourg, France. Electronic address: aurelie.velay@chru-strasbourg.fr. 2. Virology Laboratory, University Hospital of Strasbourg, F-67000 Strasbourg, France; INSERM, IRM UMR_S 1109, F-67000 Strasbourg, France. 3. Centre National de Référence (CNR) des Arbovirus, Institut de Recherche Biomédicale des Armées (IRBA), Hôpital d'Instruction des Armées Laveran, F-13013 Marseille, France. 4. Service de Médecine Interne et de Rhumatologie, Hôpitaux Civils de Colmar, F-68000 Colmar, France. 5. Laboratoire de Microbiologie, Hôpitaux Civils de Colmar, F-68000 Colmar, France. 6. Service de Médecine interne-Maladies systémiques et auto-immunes rares, Groupe Hospitalier de la région de Mulhouse et Sud Alsace, F-68051 Mulhouse, France. 7. Laboratoire de Microbiologie, Groupe Hospitalier de la région de Mulhouse et Sud Alsace, F-68051 Mulhouse, France. 8. Département de Génétique et de Biologie Spécialisée, Laboratoire Cerba, F-95310 Saint-Ouen-L'aumône, France. 9. Département Immunologie, laboratoire Eurofins Biomnis, F-69007 Lyon, France. 10. Service des maladies infectieuses et tropicales, Hôpitaux Universitaires de Strasbourg, F-67000 Strasbourg, France. 11. EA7290 Early Bacterial Virulence, Lyme borreliosis Group, FMTS, Université de Strasbourg, F-67000 Strasbourg, France; French National Reference Center for Borrelia, University Hospital, F-67000 Strasbourg, France. 12. Santé publique France, French national public health agency, Regional unit (Cire) Alsace Lorraine Champagne Ardenne, Saint-Maurice, France. 13. Virology Laboratory, University Hospital of Strasbourg, F-67000 Strasbourg, France.
Abstract
OBJECTIVES: Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis. In 2016, in Northeastern France, we faced a TBEV infection increase, leading to a warning from the Regional Health Agency. Here, we report the confirmed TBE cases diagnosed between January 2013 and December 2016, with particular emphasis on the year 2016. METHODS: A total of 1643 blood and cerebrospinal fluid (CSF) samples from everywhere in France, corresponding to 1460 patients, were prospectively tested for anti-TBEV-specific IgM and IgG antibodies by ELISA. Additional 39 blood and CSF samples from patients with suspected Lyme neuroborreliosis were retrospectively investigated. RESULTS: The TBEV seropositivity rate was estimated to 5.89% and 54 patients were diagnosed as TBE-confirmed cases. A significant increase in TBE cases was observed during the year 2016 with 29 confirmed cases, instead of a mean of eight cases during the three previous years (p=0.0006). Six imported cases and 48 autochthonous cases, located in the Alsace region (n=43) and in the Alpine region (n=5) were reported. Forty-six patients experienced neurological impairment. Nine patients showed an incomplete recovery at last follow-up (from 15days to eight months post-infection). TBE diagnosis was performed earlier for patients taken in charge in the Alsace region than those hospitalized elsewhere in France (p=0.0087). Among the 39 patients with suspected Lyme neuroborreliosis retrospectively investigated, one showed a TBEV recent infection. CONCLUSION: The TBE increase that occurred in France in 2016 highlights the need to improve our knowledge about the true burden of TBEV infection and subsequent long-term outcomes.
OBJECTIVES:Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis. In 2016, in Northeastern France, we faced a TBEVinfection increase, leading to a warning from the Regional Health Agency. Here, we report the confirmed TBE cases diagnosed between January 2013 and December 2016, with particular emphasis on the year 2016. METHODS: A total of 1643 blood and cerebrospinal fluid (CSF) samples from everywhere in France, corresponding to 1460 patients, were prospectively tested for anti-TBEV-specific IgM and IgG antibodies by ELISA. Additional 39 blood and CSF samples from patients with suspected Lyme neuroborreliosis were retrospectively investigated. RESULTS: The TBEV seropositivity rate was estimated to 5.89% and 54 patients were diagnosed as TBE-confirmed cases. A significant increase in TBE cases was observed during the year 2016 with 29 confirmed cases, instead of a mean of eight cases during the three previous years (p=0.0006). Six imported cases and 48 autochthonous cases, located in the Alsace region (n=43) and in the Alpine region (n=5) were reported. Forty-six patients experienced neurological impairment. Nine patients showed an incomplete recovery at last follow-up (from 15days to eight months post-infection). TBE diagnosis was performed earlier for patients taken in charge in the Alsace region than those hospitalized elsewhere in France (p=0.0087). Among the 39 patients with suspected Lyme neuroborreliosis retrospectively investigated, one showed a TBEV recent infection. CONCLUSION: The TBE increase that occurred in France in 2016 highlights the need to improve our knowledge about the true burden of TBEV infection and subsequent long-term outcomes.
Authors: Andrei A Deviatkin; Ivan S Kholodilov; Yulia A Vakulenko; Galina G Karganova; Alexander N Lukashev Journal: Viruses Date: 2020-02-23 Impact factor: 5.048
Authors: Malena Bestehorn; Sebastian Weigold; Winfried V Kern; Lidia Chitimia-Dobler; Ute Mackenstedt; Gerhard Dobler; Johannes P Borde Journal: PLoS One Date: 2018-10-18 Impact factor: 3.240
Authors: Bo Albinsson; Anu E Jääskeläinen; Kairi Värv; Mateja Jelovšek; Corine GeurtsvanKessel; Sirkka Vene; Josef D Järhult; Chantal Reusken; Irina Golovljova; Tatjana Avšič-Županc; Olli Vapalahti; Åke Lundkvist Journal: Euro Surveill Date: 2020-03