Marita Macken1, Helen Dale2, Dominic Moyo3, Eunice Chakmata3, Sarita Depani4, Trijn Israels5, Dalida Niyrenda3, Simon Bailey6, George Chagaluka3, Elizabeth M Molyneux3. 1. Department of Paediatric Oncology, Birmingham Children's Hospital, Birmingham, UK. 2. Sheffield Children's Hospital, Sheffield, UK. 3. Queen Elizabeth Central Hospital, College of Medicine, Blantyre, Malawi. 4. Great Ormond Street Hospital, London, UK. 5. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. 6. Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Abstract
BACKGROUND: Kaposi sarcoma (KS) is the most common paediatric cancer in human immunodeficiency virus (HIV) endemic countries of sub-Saharan Africa, but there is little research on management and outcomes. METHODS: Children with KS at Queen Elizabeth Central Hospital, Blantyre, Malawi treated between August 2012 and March 2015 with six courses of vincristine, bleomycin and etoposide combination chemotherapy, including antiretroviral therapy (ART) if HIV infected, were studied and outcomes compared with previously reported results. FINDINGS: Fifty-six children were included; 38 (68%) were male; and 48 (86%) were HIV positive, of whom 36 (77%) were on ART at diagnosis. Median age at diagnosis was 8 years (interquartile range [IQR] 3-12) and median follow-up was 16.9 months (IQR 3.4-36.4). Quality of life improved in 45 (80%) children; the median Lansky Score increased from 80% pre-treatment to 100% post-treatment. Eighteen (32%) children had complete response to treatment. At 12 months, overall survival was 71% (95% confidence interval [CI] 56-82) and event-free survival (event = death, loss to follow-up or relapse) was 50% (95% CI 36-63). At 1 year, the risk of loss to follow-up was 13.4%. In a previous, same-site, randomized controlled study of vincristine monotherapy, vincristine and bleomycin, or oral etoposide, oral etoposide monotherapy had the best outcome with survival at 12 month of 66% (95% CI 46-80) and event-free survival of 52% (95% CI 33-68); however, loss to follow-up was not reported. CONCLUSION: Overall survival, event-free survival and quality of life appear to have improved with this three-agent combination chemotherapy; however larger, randomized studies are needed to determine optimal management.
BACKGROUND:Kaposi sarcoma (KS) is the most common paediatric cancer in human immunodeficiency virus (HIV) endemic countries of sub-Saharan Africa, but there is little research on management and outcomes. METHODS:Children with KS at Queen Elizabeth Central Hospital, Blantyre, Malawi treated between August 2012 and March 2015 with six courses of vincristine, bleomycin and etoposide combination chemotherapy, including antiretroviral therapy (ART) if HIV infected, were studied and outcomes compared with previously reported results. FINDINGS: Fifty-six children were included; 38 (68%) were male; and 48 (86%) were HIV positive, of whom 36 (77%) were on ART at diagnosis. Median age at diagnosis was 8 years (interquartile range [IQR] 3-12) and median follow-up was 16.9 months (IQR 3.4-36.4). Quality of life improved in 45 (80%) children; the median Lansky Score increased from 80% pre-treatment to 100% post-treatment. Eighteen (32%) children had complete response to treatment. At 12 months, overall survival was 71% (95% confidence interval [CI] 56-82) and event-free survival (event = death, loss to follow-up or relapse) was 50% (95% CI 36-63). At 1 year, the risk of loss to follow-up was 13.4%. In a previous, same-site, randomized controlled study of vincristine monotherapy, vincristine and bleomycin, or oral etoposide, oral etoposide monotherapy had the best outcome with survival at 12 month of 66% (95% CI 46-80) and event-free survival of 52% (95% CI 33-68); however, loss to follow-up was not reported. CONCLUSION: Overall survival, event-free survival and quality of life appear to have improved with this three-agent combination chemotherapy; however larger, randomized studies are needed to determine optimal management.
Authors: Allison Silverstein; William Kamiyango; Jimmy Villiera; Erin C Peckham-Gregory; Casey L McAtee; Michael E Scheurer; Carrie M Cox; Carrie L Kovarik; Liane R Campbell; Carl E Allen; Parth S Mehta; Peter N Kazembe; Nmazuo W Ozuah; Nader Kim El-Mallawany Journal: HIV Med Date: 2021-10-11 Impact factor: 3.094
Authors: Nader Kim El-Mallawany; Parth S Mehta; William Kamiyango; Jimmy Villiera; Erin C Peckham-Gregory; Coxcilly Kampani; Robert Krysiak; Marcia K Sanders; Carolina Caro-Vegas; Anthony B Eason; Saeed Ahmed; Gordon E Schutze; Stephen C Martin; Peter N Kazembe; Michael E Scheurer; Dirk P Dittmer Journal: Int J Cancer Date: 2018-10-31 Impact factor: 7.396