Literature DB >> 2898843

Safe, live Vibrio cholerae vaccines?

R Taylor1, C Shaw, K Peterson, P Spears, J Mekalanos.   

Abstract

Mutants of Vibrio cholerae defective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. The tcp operon has been cloned and strains of V. cholerae have been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.

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Year:  1988        PMID： 2898843     DOI： 10.1016/s0264-410x(88)80019-7

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  35 in total

1.  Type 4 pilus biogenesis and type II-mediated protein secretion by Vibrio cholerae occur independently of the TonB-facilitated proton motive force.

Authors:  Niranjan Bose; Shelley M Payne; Ronald K Taylor
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

2.  Molecular characterization of a new variant of toxin-coregulated pilus protein (TcpA) in a toxigenic non-O1/Non-O139 strain of Vibrio cholerae.

Authors:  B Nandi; R K Nandy; A C Vicente; A C Ghose
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

3.  Characterization of a periplasmic thiol:disulfide interchange protein required for the functional maturation of secreted virulence factors of Vibrio cholerae.

Authors:  J A Peek; R K Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

4.  Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus.

Authors:  D X Sun; J M Seyer; I Kovari; R A Sumrada; R K Taylor
Journal:  Infect Immun       Date:  1991-01       Impact factor: 3.441

5.  Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili.

Authors:  D Nunn; S Bergman; S Lory
Journal:  J Bacteriol       Date:  1990-06       Impact factor: 3.490

6.  Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization.

Authors:  K M Peterson; J J Mekalanos
Journal:  Infect Immun       Date:  1988-11       Impact factor: 3.441

7.  The OmpU outer membrane protein, a potential adherence factor of Vibrio cholerae.

Authors:  V Sperandio; J A Girón; W D Silveira; J B Kaper
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

8.  Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXPhi: molecular basis for origination of new strains with epidemic potential.

Authors:  S M Faruque; M N Saha; A R Alim; M J Albert; K M Islam; J J Mekalanos
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

9.  Development and characterization of recA mutants of Campylobacter jejuni for inclusion in attenuated vaccines.

Authors:  P Guerry; P M Pope; D H Burr; J Leifer; S W Joseph; A L Bourgeois
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

10.  Analysis of expression of toxin-coregulated pili in classical and El Tor Vibrio cholerae O1 in vitro and in vivo.

Authors:  G Jonson; J Holmgren; A M Svennerholm
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441
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