Yingying Han1, Yinwen Ji1, Suya Kang2, Tianyu Dong1, Zhu Zhou3, Yuqing Zhang1, Minjian Chen1, Wei Wu1, Qiuqin Tang4, Ting Chen4, Yun Wang2, Yankai Xia5. 1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing 211166, China. 2. Suzhou Affiliated Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou 215002, JiangSu Province, China. 3. Department of Pharmaceutics and Medicinal Chemistry, University of the Pacific, Stockton 95211, USA. 4. Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China. 5. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing 211166, China. Electronic address: yankaixia@njmu.edu.cn.
Abstract
BACKGROUND: Recent studies have identified that exposure to particulate matter during pregnancy could result in adverse birth outcomes, but the effects of exposure at trimester-specific intervals are inconsistent. OBJECTIVE: Our primary goal was to investigate whether particulate matter exposure during pregnancy could affect birth weight and gestational age of neonates. METHODS: A retrospective cohort study was conducted to examine the relationship between maternal particulate matter exposure and neonatal birth weight. We collected 14,455 births records linked to hospital admission records (delivery and antenatal) from January 2013 to December 2015 in Suzhou Municipal Hospital. Air monitoring data in the same timeframe were also collected from Suzhou Environmental Protection Agency. The risk of low birth weight due to the exposure to PM2.5 (with median aerodynamic diameter≤2.5μm) and PM10 (with median aerodynamic diameter≤10μm) at each trimester and throughout the entire pregnancy were assessed. Linear regression models were applied and potential confounding factors were adjusted for data analysis. Gestational age, which was another important birth outcome, and its association with maternal particulate matter exposure were also studied. RESULTS: The final analysis included 10,915 singleton live births. Using multiple linear regression models, we found that gestational exposure to PM2.5 and PM10 at 10μg/m3 increments in the second trimester led to decreases in birth weight of 4.94g (95% confidence interval: -9.828, -0.046) and 5.65g (95% confidence interval: -10.110, -1.188), respectively. However, gestational age was not significantly associated with maternal particulate matter exposure in term neonates. CONCLUSION: These findings indicate that pregnant women might be more susceptible to particulate matter during the second trimester which may lead to decreased neonatal birth weight.
BACKGROUND: Recent studies have identified that exposure to particulate matter during pregnancy could result in adverse birth outcomes, but the effects of exposure at trimester-specific intervals are inconsistent. OBJECTIVE: Our primary goal was to investigate whether particulate matter exposure during pregnancy could affect birth weight and gestational age of neonates. METHODS: A retrospective cohort study was conducted to examine the relationship between maternal particulate matter exposure and neonatal birth weight. We collected 14,455 births records linked to hospital admission records (delivery and antenatal) from January 2013 to December 2015 in Suzhou Municipal Hospital. Air monitoring data in the same timeframe were also collected from Suzhou Environmental Protection Agency. The risk of low birth weight due to the exposure to PM2.5 (with median aerodynamic diameter≤2.5μm) and PM10 (with median aerodynamic diameter≤10μm) at each trimester and throughout the entire pregnancy were assessed. Linear regression models were applied and potential confounding factors were adjusted for data analysis. Gestational age, which was another important birth outcome, and its association with maternal particulate matter exposure were also studied. RESULTS: The final analysis included 10,915 singleton live births. Using multiple linear regression models, we found that gestational exposure to PM2.5 and PM10 at 10μg/m3 increments in the second trimester led to decreases in birth weight of 4.94g (95% confidence interval: -9.828, -0.046) and 5.65g (95% confidence interval: -10.110, -1.188), respectively. However, gestational age was not significantly associated with maternal particulate matter exposure in term neonates. CONCLUSION: These findings indicate that pregnant women might be more susceptible to particulate matter during the second trimester which may lead to decreased neonatal birth weight.
Authors: Inyang Uwak; Natalie Olson; Angelica Fuentes; Megan Moriarty; Jairus Pulczinski; Juleen Lam; Xiaohui Xu; Brandie D Taylor; Samuel Taiwo; Kirsten Koehler; Margaret Foster; Weihsueh A Chiu; Natalie M Johnson Journal: Environ Int Date: 2021-01-25 Impact factor: 9.621
Authors: William Mueller; Kraichat Tantrakarnapa; Helinor Jane Johnston; Miranda Loh; Susanne Steinle; Sotiris Vardoulakis; John W Cherrie Journal: J Expo Sci Environ Epidemiol Date: 2021-02-18 Impact factor: 5.563
Authors: Yu Jin Kim; In Gyu Song; Kyoung-Nam Kim; Min Sun Kim; Sung-Hoon Chung; Yong-Sung Choi; Chong-Woo Bae Journal: Int J Environ Res Public Health Date: 2019-02-21 Impact factor: 3.390