Lisbeth Hoejkjaer Larsen1, Ivan Chrilles Zibrandtsen2, Troels Wienecke2, Troels Wesenberg Kjaer2, Mark Schram Christensen3, Jens Bo Nielsen4, Henning Langberg5. 1. CopenRehab, Department of Public Health, University of Copenhagen, 1014 Cph. K, Denmark; Section for Integrative Neuroscience, Department for Neuroscience, University of Copenhagen, 2200 Cph. N, Denmark. Electronic address: lihl@sund.ku.dk. 2. Department of Neurology, Zealand University Hospital, University of Copenhagen, 4000 Roskilde, Denmark. 3. Section for Integrative Neuroscience, Department for Neuroscience, University of Copenhagen, 2200 Cph. N, Denmark; DTU Compute, Department of Applied Mathematics and Computer Science, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark. 4. Section for Integrative Neuroscience, Department for Neuroscience, University of Copenhagen, 2200 Cph. N, Denmark. 5. CopenRehab, Department of Public Health, University of Copenhagen, 1014 Cph. K, Denmark.
Abstract
OBJECTIVE: Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke. METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand. RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC. CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke. SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.
OBJECTIVE:Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke. METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand. RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC. CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke. SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.
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