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Literature DB >> 2898768

At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

A Simeone¹, M Pannese, D Acampora, M D'Esposito, E Boncinelli.

Abstract

Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5' noncoding exon encoding different proteins containing one of the three homeodomains.

Entities: Gene Species

Mesh：

Year: 1988 PMID： 2898768 PMCID： PMC336773 DOI： 10.1093/nar/16.12.5379

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

41 in total

1. Posterior expression of a homeobox gene in early Xenopus embryos.

Authors: B G Condie; R M Harland
Journal: Development Date: 1987-09 Impact factor: 6.868

2. A human homoeo box gene specifically expressed in spinal cord during embryonic development.

Authors: A Simeone; F Mavilio; L Bottero; A Giampaolo; G Russo; A Faiella; E Boncinelli; C Peschle
Journal: Nature Date: 1986 Apr 24-30 Impact factor: 49.962

3. Discontinuous transcription and splicing in trypanosomes.

Authors: L H Van der Ploeg
Journal: Cell Date: 1986-11-21 Impact factor: 41.582

4. Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.

Authors: C P Hart; A Awgulewitsch; A Fainsod; W McGinnis; F H Ruddle
Journal: Cell Date: 1985-11 Impact factor: 41.582

5. Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.

Authors: A E Carrasco; W McGinnis; W J Gehring; E M De Robertis
Journal: Cell Date: 1984-06 Impact factor: 41.582

6. Differential and stage-related expression in embryonic tissues of a new human homoeobox gene.

Authors: F Mavilio; A Simeone; A Giampaolo; A Faiella; V Zappavigna; D Acampora; G Poiana; G Russo; C Peschle; E Boncinelli
Journal: Nature Date: 1986 Dec 18-31 Impact factor: 49.962

7. Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.

Authors: C A Hauser; A L Joyner; R D Klein; T K Learned; G R Martin; R Tjian
Journal: Cell Date: 1985-11 Impact factor: 41.582

8. Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.

Authors: R P Harvey; C J Tabin; D A Melton
Journal: EMBO J Date: 1986-06 Impact factor: 11.598

9. Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development.

Authors: M Regulski; N McGinnis; R Chadwick; W McGinnis
Journal: EMBO J Date: 1987-03 Impact factor: 11.598

10. Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology.

Authors: D J Wolgemuth; E Engelmyer; R N Duggal; E Gizang-Ginsberg; G L Mutter; C Ponzetto; C Viviano; Z F Zakeri
Journal: EMBO J Date: 1986-06 Impact factor: 11.598

36 in total

1. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas.

Authors: J J Bijl; E Rieger; J W van Oostveen; J M Walboomers; M Kreike; R Willemze; C J Meijer
Journal: Am J Pathol Date: 1997-10 Impact factor: 4.307

2. Coordinate regulation of HOX genes in human hematopoietic cells.

Authors: M C Magli; P Barba; A Celetti; G De Vita; C Cillo; E Boncinelli
Journal: Proc Natl Acad Sci U S A Date: 1991-07-15 Impact factor: 11.205

Review 3. Transcriptional complexity of the HOXA9 locus.

Authors: Relja Popovic; Frank Erfurth; Nancy Zeleznik-Le
Journal: Blood Cells Mol Dis Date: 2007-10-03 Impact factor: 3.039

4. Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a.

Authors: H Sasaki; E Yokoyama; A Kuroiwa
Journal: Nucleic Acids Res Date: 1990-04-11 Impact factor: 16.971

5. Most of the homeobox-containing Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein.

Authors: B G Condie; A H Brivanlou; R M Harland
Journal: Mol Cell Biol Date: 1990-07 Impact factor: 4.272

6. Characterization of the 3' untranslated region of the mouse homeobox gene HoxB5.

Authors: C C Yu; C J Paige; G E Wu
Journal: Experientia Date: 1995-06-14

Review 7. Mammalian homeobox-containing genes: genome organization, structure, expression and evolution.

Authors: K Schughart; C Kappen; F H Ruddle
Journal: Br J Cancer Suppl Date: 1988-12

8. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.

Authors: T R Bürglin
Journal: Nucleic Acids Res Date: 1997-11-01 Impact factor: 16.971

9. Characterization of the murine Hoxc-5 gene.

Authors: A M Geada; P L Coletta; P T Sharpe
Journal: Mamm Genome Date: 1996-01 Impact factor: 2.957

10. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.

Authors: Relja Popovic; Laurie E Riesbeck; Chinavenmeni S Velu; Aditya Chaubey; Jiwang Zhang; Nicholas J Achille; Frank E Erfurth; Katherine Eaton; Jun Lu; H Leighton Grimes; Jianjun Chen; Janet D Rowley; Nancy J Zeleznik-Le
Journal: Blood Date: 2009-02-02 Impact factor: 22.113