Mi Kyung Lee1, Ji-Young Kim2, Dong-Il Kim2, Dong-Woo Kang3, Ji-Hye Park2, Ki-Yong Ahn2, Hyuk In Yang2, Dong Hoon Lee4, Yun Ho Roh5, Ji-Won Lee6, Sang-Hui Chu7, Jeffrey A Meyerhardt8, Lee W Jones9, Nam-Kyu Kim10, Justin Y Jeon11. 1. Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Republic of Korea; Exercise Medicine Center for Diabetes and Cancer Patients, ICONS, Yonsei University, Republic of Korea. 2. Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Republic of Korea. 3. Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Republic of Korea; Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada. 4. Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Republic of Korea; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Republic of Korea. 6. Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Republic of Korea. 7. Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing Policy Research Institute, Biobehavioural Research Center, Republic of Korea. 8. Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. 9. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10. Department of Surgery, Yonsei University College of Medicine, Republic of Korea; Exercise Medicine Center for Diabetes and Cancer Patients, ICONS, Yonsei University, Republic of Korea; Cancer Prevention Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: namkyuk@yuhs.ac. 11. Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Republic of Korea; Exercise Medicine Center for Diabetes and Cancer Patients, ICONS, Yonsei University, Republic of Korea; Cancer Prevention Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jjeon@yonsei.ac.kr.
Abstract
BACKGROUND AND AIMS: Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. METHODS:One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n=62) or standard care control group (n=61) for 12weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in >18MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6min walk distance from baseline to post-intervention. RESULTS: After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1±14.7MET-h/wk. to 26.6±21.7MET-h/wk. in the exercise group, with no change in the control group (p<0.01 for group and time interaction). Circulating insulin level decreased by 1μU/ml (6.0±3.9 vs. 5.0±3.5, p=0.009) in the exercise group with no change in the control group (p=0.022 for group and time interaction). A similar trend was observed in TNF-α (p=0.030 for group and time interaction). Six minute walk distance increased by 25.2m in the exercise group with no change in the control group (p=0.061 for group and time interaction). CONCLUSIONS: The 12week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.
RCT Entities:
BACKGROUND AND AIMS: Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. METHODS: One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n=62) or standard care control group (n=61) for 12weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in >18MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6min walk distance from baseline to post-intervention. RESULTS: After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1±14.7MET-h/wk. to 26.6±21.7MET-h/wk. in the exercise group, with no change in the control group (p<0.01 for group and time interaction). Circulating insulin level decreased by 1μU/ml (6.0±3.9 vs. 5.0±3.5, p=0.009) in the exercise group with no change in the control group (p=0.022 for group and time interaction). A similar trend was observed in TNF-α (p=0.030 for group and time interaction). Six minute walk distance increased by 25.2m in the exercise group with no change in the control group (p=0.061 for group and time interaction). CONCLUSIONS: The 12week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.
Authors: R Vera; J Aparicio; F Carballo; M Esteva; E González-Flores; J Santianes; F Santolaya; J M Fernández-Cebrián Journal: Clin Transl Oncol Date: 2019-02-14 Impact factor: 3.405
Authors: Suneil Jain; Gillian Prue; Malcolm Brown; Marie Murphy; Lauri McDermott; Helen McAneney; Joe M O'Sullivan Journal: Pilot Feasibility Stud Date: 2019-08-16