Literature DB >> 2898699

Alpha-interferon therapy for essential thrombocythaemia.

F J Giles1, C R Singer, A G Gray, K L Yong, M Brozovic, S C Davies, I R Grant, A V Hoffbrand, S J Machin, A B Mehta.   

Abstract

18 patients with symptomatic essential thrombocythaemia were treated with recombinant alpha interferon (2a or 2b). Subcutaneous dosage regimens, which were well-tolerated, selectively lowered the platelet count and relieved symptoms in all patients, whether previously treated or untreated. Recombinant alpha-interferon may offer a non-leukaemogenic alternative therapy for these patients.

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Year:  1988        PMID: 2898699     DOI: 10.1016/s0140-6736(88)90005-0

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  11 in total

Review 1.  Haematology.

Authors:  N T O'Connor
Journal:  Postgrad Med J       Date:  1990-08       Impact factor: 2.401

2.  Recombinant interferon-alpha, but not interferon-gamma is effective therapy for essential thrombocythemia.

Authors:  M J Abegg-Werter; J M Raemaekers; B E de Pauw; C Haanen
Journal:  Blut       Date:  1990-01

Review 3.  Common emergencies in cancer medicine: hematologic and gastrointestinal syndromes.

Authors:  C R Thomas; I K Carter; W T Leslie; F Sutton
Journal:  J Natl Med Assoc       Date:  1992-02       Impact factor: 1.798

4.  Treatment of early stage-B chronic lymphocytic leukemia with alpha-2b interferon after chlorambucil reduction of the tumoral mass.

Authors:  E Montserrat; N Villamor; A Urbano-Ispizua; J M Ribera; M Lozano; J L Vives-Corrons; C Rozman
Journal:  Ann Hematol       Date:  1991-07       Impact factor: 3.673

Review 5.  Interferon-alpha in childhood haematological malignancies.

Authors:  R Simkó; K Nagy
Journal:  Postgrad Med J       Date:  1996-12       Impact factor: 2.401

6.  Immune thrombocytopenia and interferon alfa.

Authors:  E J Kanfer; D M McCarthy
Journal:  BMJ       Date:  1988-12-17

Review 7.  Primary thrombocythemia: diagnosis, clinical manifestations and management.

Authors:  P J van Genderen; J J Michiels
Journal:  Ann Hematol       Date:  1993-08       Impact factor: 3.673

8.  A long-term clinical trial of interferon alpha-therapy in essential thrombocythemia.

Authors:  G Middelhoff; I Boll
Journal:  Ann Hematol       Date:  1992-05       Impact factor: 3.673

Review 9.  Interferon-alpha in malignant and viral diseases. A review.

Authors:  R T Dorr
Journal:  Drugs       Date:  1993-02       Impact factor: 9.546

10.  Interferon alpha-2b in the long-term treatment of essential thrombocythemia.

Authors:  S Sacchi; A Tabilio; P Leoni; A Riccardi; A Vecchi; C Messora; F Falzetti; S Rupoli; G Ucci; M F Martelli
Journal:  Ann Hematol       Date:  1991-10       Impact factor: 3.673

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