| Literature DB >> 28986896 |
Sudipto Das1, Bruce Moran2, Antoinette S Perry3.
Abstract
Many cancer-associated epigenetic signatures are also commonly observed in stem cells, just as epigenetic stem cell patterns are in cancer cells. DNA methylation is recognized as a hallmark of cancer development and progression. Herein, we describe two approaches to analyze DNA methylation, which can be applied to study or discover DNA methylation aberrations throughout the genome, as well as a more targeted investigation of regions of interest in cancer stem cells.Entities:
Keywords: 5mC; DNA methylation; Differentially methylated regions; Methyl capture; Methylomic; PCR; Regions of interest
Mesh：
Year: 2018 PMID： 28986896 DOI： 10.1007/978-1-4939-7401-6_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745