| Literature DB >> 28986783 |
Leonardo Magalhães Cruz1,2, Sheyla Trefflich3, Vinícius Almir Weiss3, Mauro Antônio Alves Castro3.
Abstract
Protein function is a concept that can have different interpretations in different biological contexts, and the number and diversity of novel proteins identified by large-scale "omics" technologies poses increasingly new challenges. In this review we explore current strategies used to predict protein function focused on high-throughput sequence analysis, as for example, inference based on sequence similarity, sequence composition, structure, and protein-protein interaction. Various prediction strategies are discussed together with illustrative workflows highlighting the use of some benchmark tools and knowledge bases in the field.Keywords: Bioinformatics; Biological databases; Database sequence similarity search; Homology; Ontology; Phylogeny; Protein domains; Protein families; Protein function
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Year: 2017 PMID： 28986783 DOI： 10.1007/978-1-4939-7231-9_5
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745