Julio Brandao Guimaraes1,2,3, Michael C Nevitt4, Charles E McCulloch4, Benedikt J Schwaiger5, Alexandra S Gersing5, Luca Facchetti5, Matthew D Bucknor5, Nattagan Chanchek5, Felix Liu4, Gabby B Joseph5, Thomas M Link5. 1. Musculoskeletal and Quantitative Imaging Research Group (MQIR), Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA. Julio.BrandaoGuimaraes@ucsf.edu. 2. Department of Radiology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil. Julio.BrandaoGuimaraes@ucsf.edu. 3. Department of Radiology, DASA Laboratory, Sao Paulo, Brazil. Julio.BrandaoGuimaraes@ucsf.edu. 4. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. 5. Musculoskeletal and Quantitative Imaging Research Group (MQIR), Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Abstract
OBJECTIVES: To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). METHODS: We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (≥3%, n = 141), had moderate weight gain (3-10%, n = 77), substantial weight gain (>10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects' characteristics. RESULTS: Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9; 95% confidence interval [CI] 2.4-8.9) and substantial weight gain (OR, 9.5; 95% CI 3.2-28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8; 95% CI 3.5-11.3; lateral: OR, 2.6; 95% CI 1.1-6.6) and substantial weight gain (medial: OR, 21.0; 95% CI 5.1-80.7; lateral: OR, 9.7; 95% CI 0.95-100.2). CONCLUSION: Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain. KEY POINTS: • Subjects who gained weight were more likely to develop meniscal tears. • Greater amount of weight gain was associated with an increasing likelihood of progression. • Prevention of weight gain has health benefits for the meniscus.
OBJECTIVES: To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). METHODS: We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (≥3%, n = 141), had moderate weight gain (3-10%, n = 77), substantial weight gain (>10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects' characteristics. RESULTS: Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9; 95% confidence interval [CI] 2.4-8.9) and substantial weight gain (OR, 9.5; 95% CI 3.2-28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8; 95% CI 3.5-11.3; lateral: OR, 2.6; 95% CI 1.1-6.6) and substantial weight gain (medial: OR, 21.0; 95% CI 5.1-80.7; lateral: OR, 9.7; 95% CI 0.95-100.2). CONCLUSION:Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain. KEY POINTS: • Subjects who gained weight were more likely to develop meniscal tears. • Greater amount of weight gain was associated with an increasing likelihood of progression. • Prevention of weight gain has health benefits for the meniscus.
Authors: M D Bucknor; L Nardo; G B Joseph; H Alizai; W Srikhum; M C Nevitt; J A Lynch; C E McCulloch; T M Link Journal: Osteoarthritis Cartilage Date: 2015-01-12 Impact factor: 6.576
Authors: Deborah M Allen; Ling Li; Michel D Crema; Monica D Marra; Ali Guermazi; Brad T Wyman; Marie-Pierre Hellio Le Graverand; Martin Englund; Kenneth D Brandt; David J Hunter Journal: Ther Adv Musculoskelet Dis Date: 2010-12 Impact factor: 5.346
Authors: Judong Pan; Jean-Baptiste Pialat; Tom Joseph; Daniel Kuo; Gabby B Joseph; Michael C Nevitt; Thomas M Link Journal: Radiology Date: 2011-09-07 Impact factor: 11.105
Authors: P M Jungmann; M S Kraus; H Alizai; L Nardo; T Baum; M C Nevitt; C E McCulloch; G B Joseph; J A Lynch; T M Link Journal: Arthritis Care Res (Hoboken) Date: 2013-12 Impact factor: 4.794
Authors: Jan Rechsteiner; Michael T Hirschmann; Milos Dordevic; Anna L Falkowski; Enrique A Testa; Felix Amsler; Anna Hirschmann Journal: Eur Radiol Date: 2018-05-22 Impact factor: 5.315
Authors: Jess G Fiedorowicz; Lisa Brown; James Li; Sagar V Parikh; Boadie W Dunlop; Brent P Forester; Richard C Shelton; Michael E Thase; Matthew Macaluso; Kunbo Yu; John F Greden Journal: Psychopharmacol Bull Date: 2021-11-03
Authors: Gabby B Joseph; Sara Ramezanpour; Charles E McCulloch; Michael C Nevitt; John Lynch; Nancy E Lane; Valentina Pedoia; Sharmila Majumdar; Thomas M Link Journal: Obesity (Silver Spring) Date: 2021-04-01 Impact factor: 9.298
Authors: S Schirò; S C Foreman; G B Joseph; R B Souza; C E McCulloch; M C Nevitt; T M Link Journal: Skeletal Radiol Date: 2021-01-06 Impact factor: 2.128
Authors: Tina Zhang; Julio J Jauregui; Michael Foster; Jonathan D Packer; Sean J Meredith; Natalie L Leong; R Frank Henn Journal: Cartilage Date: 2020-05-20 Impact factor: 3.117
Authors: Eiva Bernotiene; Edvardas Bagdonas; Gailute Kirdaite; Paulius Bernotas; Ursule Kalvaityte; Ilona Uzieliene; Christian S Thudium; Heidi Hannula; Gabriela S Lorite; Mona Dvir-Ginzberg; Ali Guermazi; Ali Mobasheri Journal: Front Med (Lausanne) Date: 2020-10-21