OBJECTIVE: Grip strength and diabetes are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to predispose to adverse health outcomes is unknown. This study determined the interactions between diabetes and grip strength and their association with health outcomes. RESEARCH DESIGN AND METHODS: We undertook a prospective, general population cohort study by using UK Biobank. Cox proportional hazards models were used to explore the associations between both grip strength and diabetes and the outcomes of all-cause mortality and CVD incidence/mortality as well as to test for interactions between diabetes and grip strength. RESULTS: A total of 347,130 UK Biobank participants with full data available (mean age 55.9 years, BMI 27.2 kg/m2, 54.2% women) were included in the analysis, of which 13,373 (4.0%) had diabetes. Over a median follow-up of 4.9 years (range 3.3-7.8 years), 6,209 died (594 as a result of CVD), and 4,301 developed CVD. Participants with diabetes were at higher risk of all-cause and CVD mortality and CVD incidence. Significant interactions (P < 0.05) existed whereby the risk of CVD mortality was higher in participants with diabetes with low (hazard ratio [HR] 4.05 [95% CI 2.72, 5.80]) versus high (HR 1.46 [0.87, 2.46]) grip strength. Similar results were observed for all-cause mortality and CVD incidence. CONCLUSIONS: Risk of adverse health outcomes among people with diabetes is lower in those with high grip strength. Low grip strength may be useful to identify a higher-risk subgroup of patients with diabetes. Intervention studies are required to determine whether resistance exercise can reduce risk.
OBJECTIVE: Grip strength and diabetes are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to predispose to adverse health outcomes is unknown. This study determined the interactions between diabetes and grip strength and their association with health outcomes. RESEARCH DESIGN AND METHODS: We undertook a prospective, general population cohort study by using UK Biobank. Cox proportional hazards models were used to explore the associations between both grip strength and diabetes and the outcomes of all-cause mortality and CVD incidence/mortality as well as to test for interactions between diabetes and grip strength. RESULTS: A total of 347,130 UK Biobank participants with full data available (mean age 55.9 years, BMI 27.2 kg/m2, 54.2% women) were included in the analysis, of which 13,373 (4.0%) had diabetes. Over a median follow-up of 4.9 years (range 3.3-7.8 years), 6,209 died (594 as a result of CVD), and 4,301 developed CVD. Participants with diabetes were at higher risk of all-cause and CVD mortality and CVD incidence. Significant interactions (P < 0.05) existed whereby the risk of CVD mortality was higher in participants with diabetes with low (hazard ratio [HR] 4.05 [95% CI 2.72, 5.80]) versus high (HR 1.46 [0.87, 2.46]) grip strength. Similar results were observed for all-cause mortality and CVD incidence. CONCLUSIONS: Risk of adverse health outcomes among people with diabetes is lower in those with high grip strength. Low grip strength may be useful to identify a higher-risk subgroup of patients with diabetes. Intervention studies are required to determine whether resistance exercise can reduce risk.
Authors: Carlos A Celis-Morales; Paul Welsh; Donald M Lyall; Lewis Steell; Fanny Petermann; Jana Anderson; Stamatina Iliodromiti; Anne Sillars; Nicholas Graham; Daniel F Mackay; Jill P Pell; Jason M R Gill; Naveed Sattar; Stuart R Gray Journal: BMJ Date: 2018-05-08
Authors: Carlos A Celis-Morales; Donald M Lyall; Lewis Steell; Stuart R Gray; Stamatina Iliodromiti; Jana Anderson; Daniel F Mackay; Paul Welsh; Thomas Yates; Jill P Pell; Naveed Sattar; Jason M R Gill Journal: BMC Med Date: 2018-05-24 Impact factor: 8.775
Authors: Ebaa Al Ozairi; Dalal Alsaeed; Dennis Taliping; Mohamad Jalali; Abeer El Samad; Anant Mashankar; Etab Taghadom; Nicola Guess; Jason M R Gill; Naveed Sattar; Cindy Gray; Paul Welsh; Stuart R Gray Journal: Trials Date: 2020-06-22 Impact factor: 2.279
Authors: Kerstin Gutefeldt; Simon Lundstedt; Ingrid S M Thyberg; Margareta Bachrach-Lindström; Hans J Arnqvist; Anna Spångeus Journal: J Diabetes Res Date: 2020-03-11 Impact factor: 4.011