F Araya-Quintanilla1, H Gutiérrez-Espinoza2, U Sánchez-Montoya3, M J Muñoz-Yañez4, A Baeza-Vergara3, M Petersen-Yanjarí3, L Fernández-Lecaros3. 1. Universidad de las Américas, Facultad de Ciencias de la Salud, Santiago, Chile. Electronic address: fandres.kine@gmail.com. 2. Universidad de las Américas, Facultad de Ciencias de la Salud, Santiago, Chile; Unidad de Kinesiología, Centro de Diagnóstico y Tratamiento (CDT), Hospital Clínico San Borja-Arriarán, Santiago, Chile. 3. Universidad de las Américas, Facultad de Ciencias de la Salud, Escuela de Nutrición y Dietética, Santiago, Chile. 4. Universidad Gabriela Mistral, Facultad de Ciencias de la Salud, Escuela de Kinesiología, Santiago, Chile.
Abstract
INTRODUCTION: Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction. METHODS: We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD. OBJECTIVE: To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD. SEARCH STRATEGY: We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar. STUDY SELECTION: Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method. CONCLUSION: There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term.
INTRODUCTION:Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction. METHODS: We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD. OBJECTIVE: To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD. SEARCH STRATEGY: We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar. STUDY SELECTION: Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method. CONCLUSION: There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in ADpatients in the short and medium term.
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