Jennifer Mancio1, Marilia Pinheiro2, Wilson Ferreira3, Monica Carvalho3, Antonio Barros4, Nuno Ferreira3, Luis Vouga5, Vasco Gama Ribeiro3, Adelino Leite-Moreira6, Ines Falcao-Pires4, Nuno Bettencourt4. 1. Department of Cardiothoracic Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal; Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia, Portugal. Electronic address: up200104593@med.up.pt. 2. Faculty of Food and Nutrition, University of Porto, Portugal. 3. Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia, Portugal. 4. Department of Cardiothoracic Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal. 5. Department of Cardiothoracic Surgery, Centro Hospitalar de Vila Nova de Gaia, Portugal. 6. Department of Cardiothoracic Surgery and Physiology, Faculty of Medicine, University of Porto, Portugal; Department of Cardiothoracic Surgery, Centro Hospitalar de Sao Joao, Portugal.
Abstract
BACKGROUND: The association of epicardial adipose tissue (EAT) and coronary artery calcification (CAC) seems to differ by gender. However, few studies have controlled for body size, and the ideal method for body size indexing has not been explored. OBJECTIVES: To analyse the effect of gender related-body size and-body fat differences on the association of EAT with CAC. METHODS: This was a prospective cohort of 371 severe aortic stenosis patients (77±8.5year-old, 51% females) referred to cardiac surgery. Agatston calcium score, EAT volume and visceral abdominal fat (VAF) were obtained by computed tomography. Body composition was determined using bioelectrical impedance analysis. Body weight and height were measured to derive body mass index (BMI), body surface area (BSA), and body surface index (BSI). EAT volume was normalized for BSA, weight and height. RESULTS: Median CAC score was higher in men (887; IQR: 2010) than in women (279: IQR: 145) (p<0.01). Similarly, men had higher volume of EAT than women (137±65.6 vs. 106±65.6mL, p<0.01), even when BSA- or height-indexed, but not if weight-indexed. EAT volume was associated with CAC adjusting for adiposity (BMI or BSI and VAF, or fat mass), but not with further adjustment for gender. In a stratified analysis, absolute- and indexed-volumes of EAT were independently associated with CAC in men while no association was found in women (gender-interaction p<0.05). CONCLUSIONS: In these high-risk patients, we demonstrated that EAT was associated with CAC score irrespective of body size, body fat and cardiovascular risk factors in men but not in women.
BACKGROUND: The association of epicardial adipose tissue (EAT) and coronary artery calcification (CAC) seems to differ by gender. However, few studies have controlled for body size, and the ideal method for body size indexing has not been explored. OBJECTIVES: To analyse the effect of gender related-body size and-body fat differences on the association of EAT with CAC. METHODS: This was a prospective cohort of 371 severe aortic stenosispatients (77±8.5year-old, 51% females) referred to cardiac surgery. Agatston calcium score, EAT volume and visceral abdominal fat (VAF) were obtained by computed tomography. Body composition was determined using bioelectrical impedance analysis. Body weight and height were measured to derive body mass index (BMI), body surface area (BSA), and body surface index (BSI). EAT volume was normalized for BSA, weight and height. RESULTS: Median CAC score was higher in men (887; IQR: 2010) than in women (279: IQR: 145) (p<0.01). Similarly, men had higher volume of EAT than women (137±65.6 vs. 106±65.6mL, p<0.01), even when BSA- or height-indexed, but not if weight-indexed. EAT volume was associated with CAC adjusting for adiposity (BMI or BSI and VAF, or fat mass), but not with further adjustment for gender. In a stratified analysis, absolute- and indexed-volumes of EAT were independently associated with CAC in men while no association was found in women (gender-interaction p<0.05). CONCLUSIONS: In these high-risk patients, we demonstrated that EAT was associated with CAC score irrespective of body size, body fat and cardiovascular risk factors in men but not in women.
Authors: Evangelos Tzolos; Michelle C Williams; Priscilla McElhinney; Andrew Lin; Kajetan Grodecki; Guadalupe Flores Tomasino; Sebastien Cadet; Jacek Kwiecinski; Mhairi Doris; Philip D Adamson; Alastair J Moss; Shirjel Alam; Amanda Hunter; Anoop S V Shah; Nicholas L Mills; Tania Pawade; Chengjia Wang; Jonathan R Weir-McCall; Giles Roditi; Edwin J R van Beek; Leslee J Shaw; Edward D Nicol; Daniel S Berman; Piotr J Slomka; Marc R Dweck; David E Newby; Damini Dey Journal: JACC Cardiovasc Imaging Date: 2022-04-13
Authors: Jeremy Yuvaraj; Mourushi Isa; Zhu Chung Che; Egynne Lim; Nitesh Nerlekar; Stephen J Nicholls; Sujith Seneviratne; Andrew Lin; Damini Dey; Dennis T L Wong Journal: Sci Rep Date: 2022-06-10 Impact factor: 4.996
Authors: Regitse H Christensen; Bernt Johan von Scholten; Christian S Hansen; Magnus T Jensen; Tina Vilsbøll; Peter Rossing; Peter G Jørgensen Journal: Cardiovasc Diabetol Date: 2019-08-30 Impact factor: 9.951