Felicity Astin1, Judith Horrocks2, Jim McLenachan3, Daniel J Blackman3, John Stephenson4, S José Closs2. 1. Centre for Applied Health Research, School of Human and Health Sciences, University of Huddersfield, UK; Research and Development, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, UK. Electronic address: Felicity.Astin@cht.nhs.uk. 2. School of Healthcare, University of Leeds, UK. 3. Department of Cardiology, Leeds Teaching Hospitals, Leeds, UK. 4. Centre for Applied Health Research, School of Human and Health Sciences, University of Huddersfield, UK.
Abstract
OBJECTIVE: To provide an in-depth understanding of patients' views about the impact of transcatheter aortic valve implantation on self-reported quality of life. BACKGROUND: Transcatheter aortic valve implantation is considered to be the gold standard of care for inoperable patients diagnosed with severe symptomatic aortic stenosis. Mid- to long-term clinical outcomes are favourable and questionnaire data indicates improvements in quality of life but an in-depth understanding of how quality of life is altered by the intervention is missing. METHODS: A mixed methods study design with a total of 89 in-depth qualitative interviews conducted with participants (39% male; mean age 81.7 years), 1 and 3 months post TAVI, recruited from a regional centre in England. Data were triangulated with questionnaire data (SF-36 and EQ5D-VAS) collected, pre, 1 and 3 months post implantation. RESULTS: Participants' accounts were characterised by four key themes; shortened life, extended life, limited life and changed life. Quality of life was changed through two mechanisms. Most participants reported a reduced symptom burden and all explained that their life expectancy was improved. Questionnaire data supported interview data with gradual improvements in mean EQ-5D scores and SF-36 physical and mental domain scores at 1 and 3 months compared to baseline. CONCLUSION: Findings suggest that TAVI was of variable benefit, producing considerable improvements in either mental or physical health in many participants, while a smaller proportion continued to deteriorate.
OBJECTIVE: To provide an in-depth understanding of patients' views about the impact of transcatheter aortic valve implantation on self-reported quality of life. BACKGROUND: Transcatheter aortic valve implantation is considered to be the gold standard of care for inoperable patients diagnosed with severe symptomatic aortic stenosis. Mid- to long-term clinical outcomes are favourable and questionnaire data indicates improvements in quality of life but an in-depth understanding of how quality of life is altered by the intervention is missing. METHODS: A mixed methods study design with a total of 89 in-depth qualitative interviews conducted with participants (39% male; mean age 81.7 years), 1 and 3 months post TAVI, recruited from a regional centre in England. Data were triangulated with questionnaire data (SF-36 and EQ5D-VAS) collected, pre, 1 and 3 months post implantation. RESULTS: Participants' accounts were characterised by four key themes; shortened life, extended life, limited life and changed life. Quality of life was changed through two mechanisms. Most participants reported a reduced symptom burden and all explained that their life expectancy was improved. Questionnaire data supported interview data with gradual improvements in mean EQ-5D scores and SF-36 physical and mental domain scores at 1 and 3 months compared to baseline. CONCLUSION: Findings suggest that TAVI was of variable benefit, producing considerable improvements in either mental or physical health in many participants, while a smaller proportion continued to deteriorate.
Authors: Constanze Hübner; Mariya Lorke; Annika Buchholz; Stefanie Frech; Laura Harzheim; Sabine Schulz; Saskia Jünger; Christiane Woopen Journal: Int J Environ Res Public Health Date: 2022-06-07 Impact factor: 4.614
Authors: Jimmy Schenk; Eline Kho; Santino Rellum; Joris Kromhout; Alexander P J Vlaar; Jan Baan; Martijn S van Mourik; Harald T Jorstad; Björn J P van der Ster; Berend E Westerhof; Steffen Bruns; Rogier V Immink; Marije M Vis; Denise P Veelo Journal: Front Cardiovasc Med Date: 2022-09-16