Anna L Ells1, Jason D Wesolosky2, April D Ingram3, Patrick C Mitchell4, Alexander S Platt3. 1. Calgary Retina Consultants, Calgary, Alberta, Canada; University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada. Electronic address: annaells@mac.com. 2. Department of Ophthalmology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 3. Calgary Retina Consultants, Calgary, Alberta, Canada. 4. University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada; Mitchell Eye Center, Calgary, Alberta, Canada.
Abstract
OBJECTIVE: The aim of this study was to evaluate the visual and structural outcomes of eyes that received ranibizumab as treatment for retinopathy of prematurity (ROP). METHODS: This was a retrospective case series of infants who received a 0.2 mg (0.02 mL) intravitreal injection of ranibizumab as the primary treatment for type 1 ROP. Outcome measures included regression or recurrence of ROP, complications of treatment, and assessment of visual acuity and refractive error. RESULTS: Forty-two eyes of 21 infants (13 male) were included. Mean gestational age and birth weight were 24.6 ± 1.3 weeks and 613 ± 91 g, respectively. Mean age at injection was 37.4 ± 2.2 weeks postmenstrual age, and mean follow-up period was 10.1 ± 7 months. Active neovascularization regressed rapidly, and anatomical outcomes were favourable in all eyes. Twelve eyes of 6 infants received supplemental laser photocoagulation at a mean post-menstrual age (PMA) of 72.0 ± 27.3 weeks when vascularization had not advanced beyond zone II. Visual acuity was measurable in 28 of 42 eyes. Mean visual acuity was 0.94 ± 0.36 logMAR. Mean spherical equivalent was +1.00. There were no ocular or systemic complications in these patients and no cicatricial complications were observed with no progression to stage 4 or 5 disease. CONCLUSIONS: A single intravitreal dose of 0.2 mg (0.02 mL) ranibizumab showed favourable anatomical and functional outcomes in eyes with type 1 ROP.
OBJECTIVE: The aim of this study was to evaluate the visual and structural outcomes of eyes that received ranibizumab as treatment for retinopathy of prematurity (ROP). METHODS: This was a retrospective case series of infants who received a 0.2 mg (0.02 mL) intravitreal injection of ranibizumab as the primary treatment for type 1 ROP. Outcome measures included regression or recurrence of ROP, complications of treatment, and assessment of visual acuity and refractive error. RESULTS: Forty-two eyes of 21 infants (13 male) were included. Mean gestational age and birth weight were 24.6 ± 1.3 weeks and 613 ± 91 g, respectively. Mean age at injection was 37.4 ± 2.2 weeks postmenstrual age, and mean follow-up period was 10.1 ± 7 months. Active neovascularization regressed rapidly, and anatomical outcomes were favourable in all eyes. Twelve eyes of 6 infants received supplemental laser photocoagulation at a mean post-menstrual age (PMA) of 72.0 ± 27.3 weeks when vascularization had not advanced beyond zone II. Visual acuity was measurable in 28 of 42 eyes. Mean visual acuity was 0.94 ± 0.36 logMAR. Mean spherical equivalent was +1.00. There were no ocular or systemic complications in these patients and no cicatricial complications were observed with no progression to stage 4 or 5 disease. CONCLUSIONS: A single intravitreal dose of 0.2 mg (0.02 mL) ranibizumab showed favourable anatomical and functional outcomes in eyes with type 1 ROP.
Authors: Rolf F Maier; Helmut Hummler; Ulrich Kellner; Tim U Krohne; Burkhard Lawrenz; Birgit Lorenz; Barbara Mitschdörfer; Claudia Roll; Andreas Stahl Journal: Ophthalmologie Date: 2022-05-04
Authors: Rolf F Maier; Helmut Hummler; Ulrich Kellner; Tim U Krohne; Burkhard Lawrenz; Birgit Lorenz; Barbara Mitschdörfer; Claudia Roll; Andreas Stahl Journal: Ophthalmologe Date: 2021-03-10 Impact factor: 1.059