| Literature DB >> 28985723 |
Sandra Wagner1,2, Marie Metzger1, Martin Flamant3, Pascal Houillier4,5, Jean-Philippe Haymann6, François Vrtovsnik3, Eric Thervet5,7, Jean-Jacques Boffa6, Ziad A Massy1,2,8, Bénédicte Stengel9,10, Patrick Rossignol2,11.
Abstract
Entities:
Year: 2017 PMID: 28985723 PMCID: PMC5629754 DOI: 10.1186/s12882-017-0723-2
Source DB: PubMed Journal: BMC Nephrol ISSN: 1471-2369 Impact factor: 2.388
Odds ratios of low or high plasma potassium associated with baseline patient characteristics – Multinomial logistic regression using patients with plasma potassium of 4–5 mmol/L as the reference group
| Plasma potassium (mmol/L) | |||
|---|---|---|---|
| <4 | >5 | ||
| Age (per year) | 0.99 (0.98–1.00) | 0.98 (0.96–0.99) | |
| Women vs men | 1.49 (1.16–1.90) | 0.47 (0.30–0.72) | |
| Sub-Saharan vs other ethnicity | 1.35 (0.99–1.83) | 1.15 (0.66–1.99) | |
| mGFR (ml/min/1.73m2) | |||
| <15 | 0.11 (0.05–0.23) | 29.65 (10.87–80.88) | |
| 15–30 | 0.26 (0.18–0.38) | 13.58 (5.71–32.3) | |
| 30–45 | 0.47 (0.34–0.63) | 5.70 (2.42–13.45) | |
| 45–60 | 0.67 (0.49–0.90) | 2.70 (1.07–6.85) | |
| >60 | 1 | 1 | |
| BMI | |||
| <19 | 1.46 (0.83–2.59) | 1.49 (0.65–3.43) | |
| 19–25 | 1 | 1 | |
| 25–30 | 0.85 (0.66–1.10) | 0.78 (0.51–1.20) | |
| >30 | 0.78 (0.57–1.07) | 1.05 (0.65–1.73) | |
| Smoking status | |||
| Never smoked | 1 | 1 | |
| Former smoker | 0.85 (0.66–1.11) | 1.02 (0.67–1.54) | |
| Active smoker | 0.76 (0.54–1.06) | 1.66 (1.03–2.67) | |
| Mean blood pressure (per mmHg) | 1.01 (1.00–1.02) | 1.01 (0.99–1.02) | |
| Cardio-vascular history | 0.63 (0.46–0.88) | 0.81 (0.51–1.28) | |
| ACR (mg/mmol) | |||
| <3 | 1 | 1 | |
| 3–30 | 1.07 (0.82–1.40) | 1.25 (0.76–2.08) | |
| >30 | 0.80 (0.59–1.10) | 1.13 (0.67–1.90) | |
| Diabetes | 0.86 (0.66–1.13) | 1.56 (1.04–2.34) | |
| Urine potassium | 0.99 (0.99–1.00) | 1.01 (1.00–1.01) | |
| Serum albumin | |||
| ≥35 | 1 | 1 | |
| <35 | 1.23 (0.87–1.74) | 1.23 (0.76–1.98) | |
| Serum potassium increasing drugsa | 0.58 (0.44–0.78) | 2.50 (1.17–5.35) | |
| Serum potassium-lowering drugsb | 1.70 (1.33–2.17) | 1.01 (0.69–1.49) | |
a loop or thiazide diuretic, kayexalate or bicarbonates b ACEi or ARBs or potassium-sparing diuretics
BMI body mass index, CVD cardiovascular disease, mGFR measured GFR, ACR, ratio of urinary albumin to creatinine
The analyses was adjusted for center
Odds ratios of low or high plasma potassium associated with baseline patient characteristics – Multinomial logistic regression using patients with plasma potassium of 4–5 mmol/L as the reference group
| Plasma potassium (mmol/L) | |||
|---|---|---|---|
| <4 | >5 | ||
| Age (per year) | 0.99 (0.98–1.00) | 0.98 (0.96–0.99) | |
| Women vs men | 1.49 (1.16–1.90) | 0.47 (0.30–0.72) | |
| Sub-Saharan vs other ethnicity | 1.35 (0.99–1.83) | 1.15 (0.66–1.99) | |
| mGFR (ml/min/1.73m2) | |||
| <15 | 0.11 (0.05–0.23) | 29.65 (10.87–80.88) | |
| 15–30 | 0.26 (0.18–0.38) | 13.58 (5.71–32.3) | |
| 30–45 | 0.47 (0.34–0.63) | 5.70 (2.42–13.45) | |
| 45–60 | 0.67 (0.49–0.90) | 2.70 (1.07–6.85) | |
| >60 | 1 | 1 | |
| BMI | |||
| <19 | 1.46 (0.83–2.59) | 1.49 (0.65–3.43) | |
| 19–25 | 1 | 1 | |
| 25–30 | 0.85 (0.66–1.10) | 0.78 (0.51–1.20) | |
| >30 | 0.78 (0.57–1.07) | 1.05 (0.65–1.73) | |
| Smoking status | |||
| Never smoked | 1 | 1 | |
| Former smoker | 0.85 (0.66–1.11) | 1.02 (0.67–1.54) | |
| Active smoker | 0.76 (0.54–1.06) | 1.66 (1.03–2.67) | |
| Mean blood pressure (per mmHg) | 1.01 (1.00–1.02) | 1.01 (0.99–1.02) | |
| Cardio-vascular history | 0.63 (0.46–0.88) | 0.81 (0.51–1.28) | |
| ACR (mg/mmol) | |||
| <3 | 1 | 1 | |
| 3–30 | 1.07 (0.82–1.40) | 1.25 (0.76–2.08) | |
| >30 | 0.80 (0.59–1.10) | 1.13 (0.67–1.90) | |
| Diabetes | 0.86 (0.66–1.13) | 1.56 (1.04–2.34) | |
| Urine potassium | 0.99 (0.99–1.00) | 1.01 (1.00–1.01) | |
| Serum albumin | |||
| ≥35 | 1 | 1 | |
| <35 | 1.23 (0.87–1.74) | 1.23 (0.76–1.98) | |
| Serum potassium increasing drugsa | 0.58 (0.44–0.78) | 2.50 (1.17–5.35) | |
| Serum potassium-lowering drugsb | 1.70 (1.33–2.17) | 1.01 (0.69–1.49) | |
a ACEi or ARBs or potassium-sparing diuretics b loop or thiazide diuretic, kayexalate or bicarbonates
BMI, body mass index, CVD, cardiovascular disease, mGFR, measured GFR, ACR, ratio of urinary albumin to creatinine
The analyses was adjusted for center