Literature DB >> 28985555

Gene Discovery for Complex Traits: Lessons from Africa.

Jon M McClellan1, Thomas Lehner2, Mary-Claire King3.   

Abstract

The genetics of African populations reveals an otherwise "missing layer" of human variation that arose between 100,000 and 5 million years ago. Both the vast number of these ancient variants and the selective pressures they survived yield insights into genes responsible for complex traits in all populations.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28985555     DOI： 10.1016/j.cell.2017.09.037

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  17 in total

Review 1.  Evaluating the promise of inclusion of African ancestry populations in genomics.

Authors:  Amy R Bentley; Shawneequa L Callier; Charles N Rotimi
Journal:  NPJ Genom Med       Date:  2020-02-25       Impact factor: 8.617

2.  From one human genome to a complex tapestry of ancestry.

Authors:  Charles N Rotimi; Adebowale A Adeyemo
Journal:  Nature       Date:  2021-02       Impact factor: 49.962

3.  The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research.

Authors:  Amy R Bentley; Shawneequa Callier; Charles Rotimi
Journal:  Ethn Dis       Date:  2019-02-21       Impact factor: 1.847

4.  Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.

Authors:  Daniel H Katz; Usman A Tahir; Alexander G Bick; Akhil Pampana; Debby Ngo; Mark D Benson; Zhi Yu; Jeremy M Robbins; Zsu-Zsu Chen; Daniel E Cruz; Shuliang Deng; Laurie Farrell; Sumita Sinha; Alec A Schmaier; Dongxiao Shen; Yan Gao; Michael E Hall; Adolfo Correa; Russell P Tracy; Peter Durda; Kent D Taylor; Yongmei Liu; W Craig Johnson; Xiuqing Guo; Jie Yao; Yii-Der Ida Chen; Ani W Manichaikul; Deepti Jain; Claude Bouchard; Mark A Sarzynski; Stephen S Rich; Jerome I Rotter; Thomas J Wang; James G Wilson; Pradeep Natarajan; Robert E Gerszten
Journal:  Circulation       Date:  2021-11-24       Impact factor: 39.918

Review 5.  Genetic Variation, Comparative Genomics, and the Diagnosis of Disease.

Authors:  Evan E Eichler
Journal:  N Engl J Med       Date:  2019-07-04       Impact factor: 91.245

Review 6.  Cognitive Genomics: Recent Advances and Current Challenges.

Authors:  Joan Fitzgerald; Derek W Morris; Gary Donohoe
Journal:  Curr Psychiatry Rep       Date:  2020-01-10       Impact factor: 5.285

7.  Genetics of schizophrenia in the South African Xhosa.

Authors:  S Gulsuner; D J Stein; E S Susser; G Sibeko; A Pretorius; T Walsh; L Majara; M M Mndini; S G Mqulwana; O A Ntola; S Casadei; L L Ngqengelele; V Korchina; C van der Merwe; M Malan; K M Fader; M Feng; E Willoughby; D Muzny; A Baldinger; H F Andrews; R C Gur; R A Gibbs; Z Zingela; M Nagdee; R S Ramesar; M-C King; J M McClellan
Journal:  Science       Date:  2020-01-31       Impact factor: 63.714

8.  Missing compared to what? Revisiting heritability, genes and culture.

Authors:  Marcus W Feldman; Sohini Ramachandran
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-04-05       Impact factor: 6.237

9.  Adaptation and validation of a computerized neurocognitive battery in the Xhosa of South Africa.

Authors:  J Cobb Scott; Tyler M Moore; Dan J Stein; Adele Pretorius; Zukiswa Zingela; Mohammed Nagdee; Linda Ngqengelele; Megan Campbell; Goodman Sibeko; Mary Claire King; Jon M McClellan; Allison M Port; Chad Jackson; Kosha Ruparel; Ezra S Susser; Ruben C Gur
Journal:  Neuropsychology       Date:  2021-07-05       Impact factor: 3.424

10.  Predictors of consent to cell line creation and immortalisation in a South African schizophrenia genomics study.

Authors:  Megan M Campbell; Jantina de Vries; Sibonile G Mqulwana; Michael M Mndini; Odwa A Ntola; Deborah Jonker; Megan Malan; Adele Pretorius; Zukiswa Zingela; Stephanus Van Wyk; Dan J Stein; Ezra Susser
Journal:  BMC Med Ethics       Date:  2018-07-11       Impact factor: 2.652
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