Ricardo Teles1,2, Kevin Moss3, John S Preisser4, Robert Genco5, William V Giannobile6, Patricia Corby7, Nathalia Garcia8, Heather Jared9, Gay Torresyap2, Elida Salazar2, Julie Moya7, Cynthia Howard7, Robert Schifferle5, Karen L Falkner5, Jane Gillespie8, Debra Dixon8, MaryAnn Cugini2. 1. Department of Periodontics, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2. Department of Applied Oral Sciences, Forsyth Institute, Cambridge, MA, USA. 3. Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 4. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 5. Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA. 6. Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, MI, USA. 7. New York University College of Dentistry, Bluestone Center for Clinical Research, New York, NY, USA. 8. Section of Periodontics, Department of Applied Dental Medicine, Southern Illinois University School of Dental Medicine, Alton, IL, USA. 9. Rho Inc., Contract Research Organization, Chapel Hill, NC, USA.
Abstract
AIM: The goal of the present longitudinal cohort study was to examine patterns of periodontal disease progression at progressing sites and subjects defined based on linear mixed models (LMM) of clinical attachment loss (CAL). MATERIALS AND METHODS: A total of 113 periodontally healthy and 302 periodontitis subjects had their CAL calculated bimonthly for 12 months. LMMs were fitted for each site and the predicted CAL levels used to categorize their progression state. Participants were grouped based on the number of progressing sites into unchanged, transitional and active subjects. Patterns of periodontal disease progression were explored using descriptive statistics. RESULTS: Progression occurred primarily at molars (50% of progressing sites) and inter-proximal sites (72%), affected a higher proportion of deep than shallow sites (2.7% versus 0.7%), and pocketing was the main mode of progression (49%). We found a low level of agreement (47%) between the LMM and traditional approaches to determine progression such as change in CAL ≥3 mm. Fourteen per cent of subjects were classified as active and among those 93% had periodontitis. The annual mean rate of progression for the active subjects was 0.35 mm/year. CONCLUSION: Progressing sites and subjects defined based on LMMs presented patterns of disease progression similar to those previously reported in the literature.
AIM: The goal of the present longitudinal cohort study was to examine patterns of periodontal disease progression at progressing sites and subjects defined based on linear mixed models (LMM) of clinical attachment loss (CAL). MATERIALS AND METHODS: A total of 113 periodontally healthy and 302 periodontitis subjects had their CAL calculated bimonthly for 12 months. LMMs were fitted for each site and the predicted CAL levels used to categorize their progression state. Participants were grouped based on the number of progressing sites into unchanged, transitional and active subjects. Patterns of periodontal disease progression were explored using descriptive statistics. RESULTS: Progression occurred primarily at molars (50% of progressing sites) and inter-proximal sites (72%), affected a higher proportion of deep than shallow sites (2.7% versus 0.7%), and pocketing was the main mode of progression (49%). We found a low level of agreement (47%) between the LMM and traditional approaches to determine progression such as change in CAL ≥3 mm. Fourteen per cent of subjects were classified as active and among those 93% had periodontitis. The annual mean rate of progression for the active subjects was 0.35 mm/year. CONCLUSION: Progressing sites and subjects defined based on LMMs presented patterns of disease progression similar to those previously reported in the literature.
Authors: Michael J LaMonte; Christopher A Andrews; Kathleen M Hovey; Michael J Buck; Lu Li; Daniel I McSkimming; Hailey R Banack; Jane Rotterman; Yijun Sun; Keith L Kirkwood; Jean Wactawski-Wende Journal: J Periodontol Date: 2020-11-03 Impact factor: 6.993