Literature DB >> 2898465

Enzyme-altered liver cell foci in woodchucks infected with woodchuck hepatitis virus.

K Abe1, T Kurata, T Shikata, B C Tennant.   

Abstract

The histochemical characteristics of liver cell foci in woodchucks were investigated. The foci appeared to be distributed throughout the liver and were observed only in the woodchuck hepatitis virus (WHV)-positive animals, including all 19 woodchucks with hepatocellular carcinoma(HCC), and 7 without HCC. No foci appeared in 11 WHV-negative animals. Histochemical studies revealed that liver cell foci and carcinoma cells were characterized by positive gamma-glutamyl transpeptidase (GGT) enzymatic reactions and decreased glucose-6-phosphatase enzyme activity compared to non-neoplastic liver. Furthermore, serum GGT was significantly elevated in almost all of the animals which had larger carcinomas. Ultrastructural findings of foci showed some resemblance to carcinoma cells, being characterized by abundant free ribosomes within the cytoplasm and undeveloped endoplasmic reticulum. These results suggest that the liver cell foci are potential precursors of HCC in WHV-infected animals, and that serum GGT may be a useful marker for indicating the development of carcinoma.

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Year:  1988        PMID： 2898465      PMCID： PMC5917495          DOI： 10.1111/j.1349-7006.1988.tb01615.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  26 in total

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Journal:  Cancer Res       Date:  1980-10       Impact factor: 12.701

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Journal:  Gan       Date:  1980-08

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  11 in total

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Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

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Authors:  F Le Guerhier; C Pichoud; C Jamard; S Guerret; M Chevallier; S Peyrol; O Hantz; I King; C Trépo; Y C Cheng; F Zoulim
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Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

6.  Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus.

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7.  [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma.

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Authors:  D Yang; R Faris; D Hixson; S Affigne; C E Rogler
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

9.  The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology.

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10.  Sequential changes in growth kinetics and cellular phenotype during hepatocarcinogenesis.

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