Jian Wang1, Shumei Chi2, Zhongke Huang1, Xiaojuan Ye1, Guohua Shi1, Dongfang Chen1, Cen Lou1. 1. Department of Nuclear Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016 Hangzhou, Zhejiang Province, China. 2. Department of Internal Neurology, Hangzhou Seventh People's Hospital, 310000 Hangzhou, Zhejiang Province, China.
Abstract
AIM: To explore the patterns of gene expression and functionally characterize the differentially expressed genes (DEGs) in thyroid cancer. METHODS: DEGs were determined between 57 paired thyroid cancer and noncancerous tissues using DESeq2. Subsequently, the main functions of the DEGs were studied by a variety of analyses. RESULTS: We identified a cohort of 752 upregulated and 309 downregulated DEGs in thyroid cancer. Several hub DEGs were found in the protein-protein interaction networks. We also revealed a set of DEGs that were dysmethylated, involved in copy number variations and associated with clinical features in thyroid cancer. CONCLUSION: These results provide some novel findings on DEGs in thyroid cancer, which will be useful to guide further investigation and target therapy for this disease. [Formula: see text].
AIM: To explore the patterns of gene expression and functionally characterize the differentially expressed genes (DEGs) in thyroid cancer. METHODS: DEGs were determined between 57 paired thyroid cancer and noncancerous tissues using DESeq2. Subsequently, the main functions of the DEGs were studied by a variety of analyses. RESULTS: We identified a cohort of 752 upregulated and 309 downregulated DEGs in thyroid cancer. Several hub DEGs were found in the protein-protein interaction networks. We also revealed a set of DEGs that were dysmethylated, involved in copy number variations and associated with clinical features in thyroid cancer. CONCLUSION: These results provide some novel findings on DEGs in thyroid cancer, which will be useful to guide further investigation and target therapy for this disease. [Formula: see text].
Entities:
Keywords:
GO ontology; KEGG pathways; differentially expressed genes; protein–protein interaction network; thyroid cancer
Authors: Vivian M L Ogundipe; Andries H Groen; Nynke Hosper; Peter W K Nagle; Julia Hess; Hette Faber; Anne L Jellema; Mirjam Baanstra; Thera P Links; Kristian Unger; John T M Plukker; Rob P Coppes Journal: Stem Cell Reports Date: 2021-03-11 Impact factor: 7.765