Dasaratha Ramaiah Jinka1, Sumanth Gandra, Gerardo Alvarez-Uria, Nuria Torre, Durgesh Tadepalli, RaghuPrakash Reddy Nayakanti. 1. Departments of Pediatrics, *Infectious Diseases, and ##Clinical Microbiology, Rural Development Trust Children's Hospital, Bathalapalli, Andhra Pradesh,India; #Center for Disease Dynamics, Economics and Policy, New Delhi, India; **Department of Pediatrics, Rural Development Trust Hospital, Kanekal,AP, India; and ‡Department of Neonatology, SJD Hospital, Barcelona, Spain. Correspondence to: Dr Dasaratha Ramaiah Jinka, Head, Department of Paediatrics, Rural Development Trust Children's Hospital, Bathalapalli, Andhra Pradesh, India. jdashrath86@gmail.com.
Abstract
OBJECTIVE: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). METHODS: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis. RESULTS: There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed. CONCLUSION: Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.
OBJECTIVE: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). METHODS: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis. RESULTS: There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed. CONCLUSION: Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.