Literature DB >> 28983637

PKC-dependent phosphorylation of Munc18a at Ser313 in activated RBL-2H3 cells.

Pratikshya Adhikari1, Hao Xu2.   

Abstract

Protein Kinase C (PKC) regulates the release of pro-inflammatory compounds from IgE/antigen-activated mast cells by unknown mechanisms. In this study, we show for the first time that PKC inhibitor Ro-03-0432, which inhibits RBL-2H3 exocytosis/degranulation in a concentration-dependent fashion, prevents the phosphorylation of membrane fusion factor Munc18a at Ser 313. Our study provides fresh evidence that PKC-dependent protein phosphorylation may contribute to the intricate regulation of mast cell degranulation by directly targeting the fusion factors.

Entities:  

Keywords:  Inflammation; Mast cell degranulation; Munc18a; Phosphorylation; Protein Kinase C; RBL-2H3

Mesh：

Substances：

Year:  2017        PMID： 28983637      PMCID： PMC5754224          DOI： 10.1007/s00011-017-1097-4

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  10 in total

1.  Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

Authors:  Shu-Hong Hu; Michelle P Christie; Natalie J Saez; Catherine F Latham; Russell Jarrott; Linda H L Lua; Brett M Collins; Jennifer L Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-30       Impact factor: 11.205

2.  Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.

Authors:  Kotaro Suzuki; Inder M Verma
Journal:  Cell       Date:  2008-08-08       Impact factor: 41.582

3.  Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Authors:  Na-Ryum Bin; Chang Hun Jung; Christopher Piggott; Shuzo Sugita
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-04       Impact factor: 11.205

4.  An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.

Authors:  Daniel Parisotto; Maximilian Pfau; Andrea Scheutzow; Klemens Wild; Matthias P Mayer; Jörg Malsam; Irmgard Sinning; Thomas H Söllner
Journal:  J Biol Chem       Date:  2014-02-14       Impact factor: 5.157

5.  Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.

Authors:  Jeff W Barclay; Tim J Craig; Richard J Fisher; Leonora F Ciufo; Gareth J O Evans; Alan Morgan; Robert D Burgoyne
Journal:  J Biol Chem       Date:  2003-01-07       Impact factor: 5.157

6.  Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.

Authors:  Y Fujita; T Sasaki; K Fukui; H Kotani; T Kimura; Y Hata; T C Südhof; R H Scheller; Y Takai
Journal:  J Biol Chem       Date:  1996-03-29       Impact factor: 5.157

7.  Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

Authors:  A M Birchall; J Bishop; D Bradshaw; A Cline; J Coffey; L H Elliott; V M Gibson; A Greenham; T J Hallam; W Harris
Journal:  J Pharmacol Exp Ther       Date:  1994-02       Impact factor: 4.030

8.  The SNARE Machinery in Mast Cell Secretion.

Authors:  Axel Lorentz; Anja Baumann; Joana Vitte; Ulrich Blank
Journal:  Front Immunol       Date:  2012-06-05       Impact factor: 7.561

9.  Differential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE Complexes.

Authors:  Hao Xu; Matthew Grant Arnold; Sushmitha Vijay Kumar
Journal:  PLoS One       Date:  2015-09-18       Impact factor: 3.240

10.  Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release.

Authors:  Ozgür Genc; Olexiy Kochubey; Ruud F Toonen; Matthijs Verhage; Ralf Schneggenburger
Journal:  Elife       Date:  2014-02-11       Impact factor: 8.140
  10 in total
  3 in total

1.  Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells.

Authors:  Berenice A Gutierrez; Miguel A Chavez; Alejandro I Rodarte; Marco A Ramos; Andrea Dominguez; Youlia Petrova; Alfredo J Davalos; Renan M Costa; Ramon Elizondo; Michael J Tuvim; Burton F Dickey; Alan R Burns; Ruth Heidelberger; Roberto Adachi
Journal:  J Biol Chem       Date:  2018-03-29       Impact factor: 5.157

2.  Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis.

Authors:  Eduardo I Cardenas; Ricardo Gonzalez; Keegan Breaux; Qi Da; Berenice A Gutierrez; Marco A Ramos; Rodolfo A Cardenas; Alan R Burns; Rolando E Rumbaut; Roberto Adachi
Journal:  J Biol Chem       Date:  2019-01-29       Impact factor: 5.157

3.  Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis.

Authors:  Elizabeth Sanchez; Erika A Gonzalez; David S Moreno; Rodolfo A Cardenas; Marco A Ramos; Alfredo J Davalos; John Manllo; Alejandro I Rodarte; Youlia Petrova; Daniel C Moreira; Miguel A Chavez; Alejandro Tortoriello; Adolfo Lara; Berenice A Gutierrez; Alan R Burns; Ruth Heidelberger; Roberto Adachi
Journal:  J Biol Chem       Date:  2018-12-18       Impact factor: 5.157
  3 in total

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