Shintaro Shiba1,2, Noriyuki Okonogi1, Shingo Kato3, Masaru Wakatsuki4,5, Daijiro Kobayashi2,6, Hiroki Kiyohara7, Tatsuya Ohno2, Kumiko Karasawa8, Takashi Nakano2, Tadashi Kamada1. 1. Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. 2. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan. 3. Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka, Japan. 4. Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan wakkun100@yahoo.co.jp. 5. Department of Radiology, Jichi Medical University, Shimotsuke, Japan. 6. Cyber Center, Kanto Neurosurgical Hospital, Kumagaya, Japan. 7. Department of Radiation Oncology, Maebashi Red Cross Hospital, Maebashi, Japan. 8. Department of Radiation Oncology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND/AIM: To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy. PATIENTS AND METHODS: Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions. RESULTS: Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively. CONCLUSION: Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients. Copyright
BACKGROUND/AIM: To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy. PATIENTS AND METHODS: Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions. RESULTS: Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively. CONCLUSION: Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients. Copyright