Tuong N G Nguyen 1 , Van-Thanh Tran 2 , Wei Duan 3 , Phuong H L Tran 3 , Thao T D Tran 4 Show Affiliations »
Abstract
BACKGROUND: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects. METHODS: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up. RESULTS: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition. CONCLUSION: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects. METHODS: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up. RESULTS: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition. CONCLUSION: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Keywords:
Nanoprecipitation; anti-solvent; nanoparticulate; poorly water-soluble drug; solvent removal technique; surfactant
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Year: 2017
PMID： 28982324 DOI： 10.2174/1389200218666171004112122
Source DB: PubMed Journal: Curr Drug Metab ISSN： 1389-2002 Impact factor: 3.731