| Literature DB >> 2898165 |
Abstract
It is argued that rapid evolution of the hominid brain was accomplished by the molecular mechanisms of "regulatory evolution" and "gene duplication". These genomic processes may have made newly elaborated brain regions--including the association neocortices and parts of the hippocampal formation, nucleus basalis of Meynert and amygdaloid body--vulnerable to Alzheimer's disease, by increasing the value of a disease-specific genomic character function. Trisomy 21, it is proposed, further increases this value.Entities:
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Year: 1988 PMID： 2898165
Source DB: PubMed Journal: Rev Neurol (Paris) ISSN： 0035-3787 Impact factor: 2.607