Psychotropic drug interactions in the patient with late-onset depression or psychosis. Part 2.

We now conclude our discussion of psychotropic drug interactions in the late-life depression or psychosis patient. We have attempted to point out the more common drug interactions, while also mentioning less well-reported, yet potentially important interactions. The outcome of such adverse reactions as we have described herein is usually of greater concern in older patients. Accordingly, this population would benefit considerably from accurate reporting of any suspected drug interactions. Although most drug interactions are usually somewhat predictable, it is very important that those interactions that are not expected otherwise be well documented. As stated elsewhere in this review, a good basic knowledge of the pharmacology of the agents in question will serve the clinician and his or her patient well.