Daniel Chow1, Peter Chang2, Brent D Weinberg3, Daniela A Bota4, Jack Grinband5, Christopher G Filippi6. 1. 1 Department of Radiology, University of California, Irvine Medical Center, Douglas Hospital, Rte 140, Rm 0115, Orange, CA 92868. 2. 2 Department of Radiology, University of California, San Francisco, San Francisco, CA. 3. 3 Department of Radiology, Emory University School of Medicine, Emory University Hospital, Atlanta, GA. 4. 4 Department of Neuro-Oncology, University of California, Irvine Medical Center, Orange, CA. 5. 5 Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY. 6. 6 Department of Radiology, North Shore University Hospital, Manhasset, NY.
Abstract
OBJECTIVE: The purpose of this review is to summarize advances in the molecular analysis of gliomas, the role genetics plays in MRI features, and how machine-learning approaches can be used to survey the tumoral environment. CONCLUSION: The genetic profile of gliomas influences the course of treatment and clinical outcomes. Though biopsy is the reference standard for determining tumor genetics, it can suffer diagnostic delays due to surgical planning and pathologic assessment. Radiogenomics may allow rapid, low-risk characterization of genetic heterogeneity.
OBJECTIVE: The purpose of this review is to summarize advances in the molecular analysis of gliomas, the role genetics plays in MRI features, and how machine-learning approaches can be used to survey the tumoral environment. CONCLUSION: The genetic profile of gliomas influences the course of treatment and clinical outcomes. Though biopsy is the reference standard for determining tumor genetics, it can suffer diagnostic delays due to surgical planning and pathologic assessment. Radiogenomics may allow rapid, low-risk characterization of genetic heterogeneity.
Authors: Joshua D Bernstock; Sam E Gary; Neil Klinger; Pablo A Valdes; Walid Ibn Essayed; Hannah E Olsen; Gustavo Chagoya; Galal Elsayed; Daisuke Yamashita; Patrick Schuss; Florian A Gessler; Pier Paolo Peruzzi; Asim K Bag; Gregory K Friedman Journal: Neurooncol Adv Date: 2022-05-26